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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8HCX

Cryo-EM structure of Endothelin1-bound ETBR-Gq complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(q) subunit alpha-1polymer24628084.81Homo sapiens
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37741055.91UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(C)		Endothelin receptor type B,Oplophorus-luciferin 2-monooxygenase catalytic subunit chimerapolymer60367882.31UniProt (P24530)
UniProt (Q9GV45)		Homo sapiens (human)ET-B,ET-BR,Endothelin receptor non-selective type,19kOLase
4D
(D)		Endothelin-1polymer212498.01UniProt (P05305)
Pfam (PF00322)		Homo sapiens (human)Preproendothelin-1,PPET1
5E
(E)		scFv16polymer28530363.01Mus musculus
6F
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
Sequence modifications
B: 7 - 345 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -5-initiating methionine
His -4-expression tag
His -3-expression tag
His -2-expression tag
His -1-expression tag
His 0-expression tag
His 1-expression tag
Gly 2-expression tag
Ser 3-expression tag
Leu 4-expression tag
Leu 5-expression tag
Gln 6-expression tag
Gly 346-expression tag
Ser 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Gly 354-expression tag
Gly 355-expression tag
Gly 356-expression tag
Gly 357-expression tag
Ser 358-expression tag
Ser 359-expression tag
Gly 360-expression tag
Val 361-expression tag
Ser 362-expression tag
Gly 363-expression tag
Trp 364-expression tag
Arg 365-expression tag
Leu 366-expression tag
Phe 367-expression tag
Lys 368-expression tag
Lys 369-expression tag
Ile 370-expression tag
Ser 371-expression tag
C: 27 - 424 (UniProt: P24530)
PDBExternal DatabaseDetails
Met -20-initiating methionine
Asp -19-expression tag
Ser -18-expression tag
Lys -17-expression tag
Gly -16-expression tag
Ser -15-expression tag
Ser -14-expression tag
Gln -13-expression tag
Lys -12-expression tag
Gly -11-expression tag
Ser -10-expression tag
Arg -9-expression tag
Leu -8-expression tag
Leu -7-expression tag
Leu -6-expression tag
Leu -5-expression tag
Leu -4-expression tag
Val -3-expression tag
Val -2-expression tag
Ser -1-expression tag
Asn 0-expression tag
Leu 1-expression tag
Leu 2-expression tag
Leu 3-expression tag
Cys 4-expression tag
Gln 5-expression tag
Gly 6-expression tag
Val 7-expression tag
Val 8-expression tag
Ser 9-expression tag
Asp 10-expression tag
Tyr 11-expression tag
Lys 12-expression tag
Asp 13-expression tag
Asp 14-expression tag
Asp 15-expression tag
Asp 16-expression tag
Val 17-expression tag
Asp 18-expression tag
His 19-expression tag
His 20-expression tag
His 21-expression tag
His 22-expression tag
His 23-expression tag
His 24-expression tag
His 25-expression tag
His 26-expression tag
C: 425 - 582 (UniProt: Q9GV45)
PDBExternal DatabaseDetails
Val 425Thr 27conflict
Glu 429Ala 31conflict
Glu 436Gln 38conflict
Ala 440Gly 42conflict
Leu 443Gln 45conflict
Val 452Leu 54conflict
Leu 456Phe 58conflict
Asn 458Ala 60conflict
Ala 460Gly 62conflict
Arg 468Lys 70conflict
Ile 469Val 71conflict
Arg 471Leu 73conflict
Ala 476Gly 78conflict
Ile 479Ala 81conflict
Ala 492Gly 94conflict
Asp 493Phe 95conflict
Ala 496Gly 98conflict
Gln 497Leu 99conflict
Glu 500Met 102conflict
Val 501Ile 103conflict
Val 515Ile 117conflict
Pro 518His 120conflict
Leu 532Ile 134conflict
Asn 533Asp 135conflict
Glu 540Pro 142conflict
Lys 549Gln 151conflict
Ile 563Tyr 165conflict
Thr 569Asn 171conflict
Met 574Leu 176conflict
Ser 582Gly 184conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight177745.2
All*Total formula weight177745.2
*Water molecules are not included.

249697

PDB entries from 2026-02-25

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