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8HCX

Cryo-EM structure of Endothelin1-bound ETBR-Gq complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007186biological_processG protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001755biological_processneural crest cell migration
C0001934biological_processpositive regulation of protein phosphorylation
C0002001biological_processrenin secretion into blood stream
C0002027biological_processregulation of heart rate
C0004930molecular_functionG protein-coupled receptor activity
C0004962molecular_functionendothelin receptor activity
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0006885biological_processregulation of pH
C0007166biological_processcell surface receptor signaling pathway
C0007186biological_processG protein-coupled receptor signaling pathway
C0007194biological_processnegative regulation of adenylate cyclase activity
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007399biological_processnervous system development
C0007422biological_processperipheral nervous system development
C0007497biological_processposterior midgut development
C0008015biological_processblood circulation
C0008217biological_processregulation of blood pressure
C0008284biological_processpositive regulation of cell population proliferation
C0010033biological_processobsolete response to organic substance
C0010467biological_processgene expression
C0014043biological_processnegative regulation of neuron maturation
C0014070biological_processresponse to organic cyclic compound
C0014826biological_processvein smooth muscle contraction
C0016020cellular_componentmembrane
C0017046molecular_functionpeptide hormone binding
C0019722biological_processcalcium-mediated signaling
C0019934biological_processcGMP-mediated signaling
C0030202biological_processheparin metabolic process
C0030318biological_processmelanocyte differentiation
C0031620biological_processregulation of fever generation
C0031702molecular_functiontype 1 angiotensin receptor binding
C0031965cellular_componentnuclear membrane
C0032341biological_processaldosterone metabolic process
C0032496biological_processresponse to lipopolysaccharide
C0035645biological_processenteric smooth muscle cell differentiation
C0035810biological_processpositive regulation of urine volume
C0035812biological_processrenal sodium excretion
C0042045biological_processepithelial fluid transport
C0042310biological_processvasoconstriction
C0042311biological_processvasodilation
C0043066biological_processnegative regulation of apoptotic process
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043473biological_processpigmentation
C0048066biological_processdevelopmental pigmentation
C0048246biological_processmacrophage chemotaxis
C0048265biological_processresponse to pain
C0048484biological_processenteric nervous system development
C0050678biological_processregulation of epithelial cell proliferation
C0051248biological_processnegative regulation of protein metabolic process
C0055078biological_processsodium ion homeostasis
C0060070biological_processcanonical Wnt signaling pathway
C0060406biological_processpositive regulation of penile erection
C0061028biological_processestablishment of endothelial barrier
C0065008biological_processregulation of biological quality
C0070294biological_processrenal sodium ion absorption
C0070588biological_processcalcium ion transmembrane transport
C0071222biological_processcellular response to lipopolysaccharide
C0071806biological_processprotein transmembrane transport
C0072112biological_processpodocyte differentiation
C0086100biological_processendothelin receptor signaling pathway
C0097018biological_processrenal albumin absorption
C0097402biological_processneuroblast migration
C0160093biological_processchordate pharynx development
C1904383biological_processresponse to sodium phosphate
C1990839biological_processresponse to endothelin
D0005576cellular_componentextracellular region
D0019229biological_processregulation of vasoconstriction
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ITVlSLCALSIDRYRaV
ChainResidueDetails
CILE187-VAL203

site_idPS00270
Number of Residues15
DetailsENDOTHELIN Endothelin family signature. CsCsslmDkeCvyFC
ChainResidueDetails
DCYS1-CYS15

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU75-SER89
BILE162-ILE176
BLEU290-ALA304
BVAL332-GLY346

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
GALA2
CALA164-LYS175
CTHR244-THR271
CASN351-SER362

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
GCYS68
CASP198-THR218
CTHR297-THR324

site_idSWS_FT_FI4
Number of Residues25
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
CILE138-LEU163

site_idSWS_FT_FI5
Number of Residues21
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
CLEU176-ILE197

site_idSWS_FT_FI6
Number of Residues24
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
CALA219-ILE243

site_idSWS_FT_FI7
Number of Residues24
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
CALA272-MET296

site_idSWS_FT_FI8
Number of Residues25
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
CVAL325-TYR350

site_idSWS_FT_FI9
Number of Residues26
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
CPHE363-VAL389

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P28088
ChainResidueDetails
CSER305
CSER419

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:9261180
ChainResidueDetails
CCYS402

site_idSWS_FT_FI12
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000255
ChainResidueDetails
CCYS403
CCYS405

site_idSWS_FT_FI13
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN59

222926

PDB entries from 2024-07-24

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