5CA0
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![BU of 5ca0 by Molmil](/molmil-images/mine/5ca0) | Crystal structure of T2R-TTL-Lexibulin complex | Descriptor: | 1-ethyl-3-[2-methoxy-4-(5-methyl-4-{[(1S)-1-(pyridin-3-yl)butyl]amino}pyrimidin-2-yl)phenyl]urea, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Wang, Y, Yu, Y, Chen, Q, Yang, J. | Deposit date: | 2015-06-29 | Release date: | 2015-11-04 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.501 Å) | Cite: | Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. Febs J., 283, 2016
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6LGW
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![BU of 6lgw by Molmil](/molmil-images/mine/6lgw) | Structure of Rabies virus glycoprotein in complex with neutralizing antibody 523-11 at acidic pH | Descriptor: | Glycoprotein, scFv 523-11 | Authors: | Yang, F.L, Lin, S, Ye, F, Yang, J, Qi, J.X, Chen, Z.J, Lin, X, Wang, J.C, Yue, D, Cheng, Y.W, Chen, Z.M, Chen, H, You, Y, Zhang, Z.L, Yang, Y, Yang, M, Sun, H.L, Li, Y.H, Cao, Y, Yang, S.Y, Wei, Y.Q, Gao, G.F, Lu, G.W. | Deposit date: | 2019-12-06 | Release date: | 2020-02-19 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.9037 Å) | Cite: | Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody. Cell Host Microbe, 27, 2020
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3LDB
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![BU of 3ldb by Molmil](/molmil-images/mine/3ldb) | Structure of JMJD6 complexd with ALPHA-KETOGLUTARATE and Fab Fragment. | Descriptor: | 2-OXOGLUTARIC ACID, Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, FE (III) ION, ... | Authors: | Hong, X, Zang, J, White, J, Kappler, J.W, Wang, C, Zhang, G. | Deposit date: | 2010-01-12 | Release date: | 2010-08-04 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Interaction of JMJD6 with single-stranded RNA. Proc.Natl.Acad.Sci.USA, 107, 2010
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5CB4
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![BU of 5cb4 by Molmil](/molmil-images/mine/5cb4) | Crystal structure of T2R-TTL-Tivantinib complex | Descriptor: | (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Wang, Y, Yu, Y, Chen, Q, Yang, J. | Deposit date: | 2015-06-30 | Release date: | 2015-11-04 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.193 Å) | Cite: | Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery. Febs J., 283, 2016
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6LGX
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![BU of 6lgx by Molmil](/molmil-images/mine/6lgx) | Structure of Rabies virus glycoprotein at basic pH | Descriptor: | Glycoprotein,Glycoprotein,Glycoprotein | Authors: | Yang, F.L, Lin, S, Ye, F, Yang, J, Qi, J.X, Chen, Z.J, Lin, X, Wang, J.C, Yue, D, Cheng, Y.W, Chen, Z.M, Chen, H, You, Y, Zhang, Z.L, Yang, Y, Yang, M, Sun, H.L, Li, Y.H, Cao, Y, Yang, S.Y, Wei, Y.Q, Gao, G.F, Lu, G.W. | Deposit date: | 2019-12-06 | Release date: | 2020-02-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.097 Å) | Cite: | Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody. Cell Host Microbe, 27, 2020
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6PMO
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![BU of 6pmo by Molmil](/molmil-images/mine/6pmo) | |
7UJJ
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![BU of 7ujj by Molmil](/molmil-images/mine/7ujj) | Stx2a and DARPin complex | Descriptor: | 1,2-ETHANEDIOL, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, DARPin, ... | Authors: | Jiang, M, Zhang, J. | Deposit date: | 2022-03-30 | Release date: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | A Multi-Specific DARPin Potently Neutralizes Shiga Toxin 2 via Simultaneous Modulation of Both Toxin Subunits. Bioengineering (Basel), 9, 2022
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7N97
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![BU of 7n97 by Molmil](/molmil-images/mine/7n97) | State 2 of TcdB and FZD2 at pH5 | Descriptor: | Frizzled-2, Toxin B | Authors: | Jiang, M, Zhang, J. | Deposit date: | 2021-06-17 | Release date: | 2022-03-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (5.1 Å) | Cite: | Structural Basis for Receptor Recognition of the Clostridium difficile Toxin B and its Dissociation upon Acidification To Be Published
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7N8X
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![BU of 7n8x by Molmil](/molmil-images/mine/7n8x) | Partial C. difficile TcdB and CSPG4 fragment | Descriptor: | Chondroitin sulfate proteoglycan 4, Toxin B | Authors: | Jiang, M, Zhang, J. | Deposit date: | 2021-06-16 | Release date: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification To Be Published
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6WGB
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![BU of 6wgb by Molmil](/molmil-images/mine/6wgb) | Crystal structure of the fab portion of dupilumab | Descriptor: | Dupilumab Fab heavy chain, Dupilumab Fab light chain | Authors: | Druzina, Z, Atwell, S, Pustilnik, A, Antonysamy, S, Ho, C, Lieu, R, Hendle, J, Benach, J, Wang, J. | Deposit date: | 2020-04-05 | Release date: | 2020-09-16 | Last modified: | 2020-09-23 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing. Plos One, 15, 2020
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7N9Q
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![BU of 7n9q by Molmil](/molmil-images/mine/7n9q) | State 3 of TcdB and FZD2 at pH5 | Descriptor: | Toxin B | Authors: | Jiang, M, Zhang, J. | Deposit date: | 2021-06-18 | Release date: | 2022-03-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification To Be Published
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7N9S
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![BU of 7n9s by Molmil](/molmil-images/mine/7n9s) | TcdB and frizzled-2 CRD complex | Descriptor: | Frizzled-2, Toxin B | Authors: | Jiang, M, Zhang, J. | Deposit date: | 2021-06-18 | Release date: | 2022-03-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (5.1 Å) | Cite: | Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification To Be Published
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7N9R
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![BU of 7n9r by Molmil](/molmil-images/mine/7n9r) | state 4 of TcdB and FZD2 at pH5 | Descriptor: | Toxin B | Authors: | Jiang, M, Zhang, J. | Deposit date: | 2021-06-18 | Release date: | 2022-03-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification To Be Published
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7N9Y
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![BU of 7n9y by Molmil](/molmil-images/mine/7n9y) | Full-length TcdB and CSPG4 (401-560) complex | Descriptor: | Chondroitin sulfate proteoglycan 4, Toxin B | Authors: | Jiang, M, Zhang, J. | Deposit date: | 2021-06-18 | Release date: | 2022-03-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification To Be Published
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7N95
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![BU of 7n95 by Molmil](/molmil-images/mine/7n95) | state 1 of TcdB and FZD2 at pH5 | Descriptor: | Frizzled-2, Toxin B | Authors: | Jiang, M, Zhang, J. | Deposit date: | 2021-06-16 | Release date: | 2022-03-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural Basis for Receptor Recognition of Clostridium difficile Toxin B and its Dissociation upon Acidification To Be Published
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8DD9
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![BU of 8dd9 by Molmil](/molmil-images/mine/8dd9) | Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144L Mutant in Complex with Inhibitor GC376 | Descriptor: | (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | Authors: | Lewandowski, E.M, Jacobs, L.M.C, Hu, Y, Tan, H, Wang, J, Chen, Y. | Deposit date: | 2022-06-17 | Release date: | 2022-07-13 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9, 2023
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6POM
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![BU of 6pom by Molmil](/molmil-images/mine/6pom) | Cryo-EM structure of the full-length Bacillus subtilis glyQS T-box riboswitch in complex with tRNA-Gly | Descriptor: | T-box GlyQS leader (155-MER), tRNAGly (75-MER) | Authors: | Li, S, Su, Z, Zhang, J, Chiu, W. | Deposit date: | 2019-07-04 | Release date: | 2019-11-20 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions. Nat.Struct.Mol.Biol., 26, 2019
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8IG4
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![BU of 8ig4 by Molmil](/molmil-images/mine/8ig4) | Crystal structure of SARS-Cov-2 main protease in complex with GC376 | Descriptor: | Non-structural protein 11, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide | Authors: | Zhou, X.L, Zhang, J, Li, J. | Deposit date: | 2023-02-20 | Release date: | 2024-03-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Basis for Coronaviral Main Proteases Inhibition by the 3CLpro Inhibitor GC376. J.Mol.Biol., 436, 2024
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6LS9
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![BU of 6ls9 by Molmil](/molmil-images/mine/6ls9) | Crystal structure of bovine herpesvirus 1 glycoprotein D | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein D | Authors: | Yue, D, Chen, Z.J, Yang, F.L, Ye, F, Lin, S, Cheng, Y.W, Wang, J.C, Chen, Z.M, Lin, X, Yang, J, Chen, H, Zhang, Z.L, You, Y, Sun, H.L, Wen, A, Wang, L.L, Zheng, Y, Cao, Y, Li, Y.H, Lu, G.W. | Deposit date: | 2020-01-17 | Release date: | 2020-06-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor. Sci Adv, 6, 2020
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6LSA
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![BU of 6lsa by Molmil](/molmil-images/mine/6lsa) | Complex structure of bovine herpesvirus 1 glycoprotein D and bovine nectin-1 IgV | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein D, ... | Authors: | Yue, D, Chen, Z.J, Yang, F.L, Ye, F, Lin, S, Cheng, Y.W, Wang, J.C, Chen, Z.M, Lin, X, Yang, J, Chen, H, Zhang, Z.L, You, Y, Sun, H.L, Wen, A, Wang, L.L, Zheng, Y, Cao, Y, Li, Y.H, Lu, G.W. | Deposit date: | 2020-01-17 | Release date: | 2020-06-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.204 Å) | Cite: | Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor. Sci Adv, 6, 2020
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5Z2S
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![BU of 5z2s by Molmil](/molmil-images/mine/5z2s) | Crystal structure of DUX4-HD2 domain | Descriptor: | Double homeobox protein 4 | Authors: | Dong, X, Zhang, W, Wu, H, Huang, J, Zhang, M, Wang, P, Zhang, H, Chen, Z, Chen, S, Meng, G. | Deposit date: | 2018-01-03 | Release date: | 2018-04-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural basis of DUX4/IGH-driven transactivation. Leukemia, 32, 2018
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3ROV
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![BU of 3rov by Molmil](/molmil-images/mine/3rov) | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus | Descriptor: | CHLORIDE ION, Insulin, PHENOL, ... | Authors: | Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. | Deposit date: | 2011-04-26 | Release date: | 2012-05-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus To be Published
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6WGK
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![BU of 6wgk by Molmil](/molmil-images/mine/6wgk) | Fab portion of dupilumab with Crystal Kappa design and intrachain disulfide | Descriptor: | Dupilumab Fab heavy chain, Dupilumab Fab light chain | Authors: | Druzina, Z, Atwell, S, Pustilnik, A, Antonysamy, S, Ho, C, Lieu, R, Hendle, J, Benach, J, Wang, J. | Deposit date: | 2020-04-05 | Release date: | 2020-09-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing. Plos One, 15, 2020
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6WGL
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![BU of 6wgl by Molmil](/molmil-images/mine/6wgl) | Dupilumab fab with Crystal Kappa design complexed with human IL-4 receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Dupilumab Fab heavy chain, ... | Authors: | Druzina, Z, Atwell, S, Pustilnik, A, Antonysamy, S, Ho, C, Lieu, R, Hendle, J, Benach, J, Wang, J. | Deposit date: | 2020-04-05 | Release date: | 2020-09-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing. Plos One, 15, 2020
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4IG4
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![BU of 4ig4 by Molmil](/molmil-images/mine/4ig4) | Crystal structure of single mutant thermostable NPPase (N86S) from Geobacillus stearothermophilus | Descriptor: | Thermostable NPPase | Authors: | Guo, Z, Wang, F, Huang, J, Qiu, R, Yang, Z, Wang, Y, Gong, W, Ji, C. | Deposit date: | 2012-12-16 | Release date: | 2013-12-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.402 Å) | Cite: | Crystal structure of thermostable NPPase from Geobacillus stearothermophilus To be Published
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