6WGK

Fab portion of dupilumab with Crystal Kappa design and intrachain disulfide

Summary for 6WGK

• Entry DOI: 10.2210/pdb6wgk/pdb
• Related: 6WG8 6WGB 6WGJ
• Descriptor: Dupilumab Fab heavy chain, Dupilumab Fab light chain (3 entities in total)
• Functional Keywords: dupilumab, hil4r, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 196134.41

Authors

Druzina, Z.,Atwell, S.,Pustilnik, A.,Antonysamy, S.,Ho, C.,Lieu, R.,Hendle, J.,Benach, J.,Wang, J. (deposition date: 2020-04-05, release date: 2020-09-16, Last modification date: 2023-10-18)

• Primary citation: Lieu, R.,Antonysamy, S.,Druzina, Z.,Ho, C.,Kang, N.R.,Pustilnik, A.,Wang, J.,Atwell, S.; Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.; Plos One, 15:e0232311-e0232311, 2020; PubMed: 32915778; DOI: 10.1371/journal.pone.0232311

Experimental method

X-RAY DIFFRACTION (1.62 Å)