6WGL

Dupilumab fab with Crystal Kappa design complexed with human IL-4 receptor

Summary for 6WGL

• Entry DOI: 10.2210/pdb6wgl/pdb
• Related: 6WG8 6WGB 6WGJ 6WGK
• Descriptor: Dupilumab Fab heavy chain, Dupilumab Fab light chain, Interleukin-4 receptor subunit alpha, ... (6 entities in total)
• Functional Keywords: dupilumab, hil4r, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 75021.45

Authors

Druzina, Z.,Atwell, S.,Pustilnik, A.,Antonysamy, S.,Ho, C.,Lieu, R.,Hendle, J.,Benach, J.,Wang, J. (deposition date: 2020-04-05, release date: 2020-09-16, Last modification date: 2023-10-18)

• Primary citation: Lieu, R.,Antonysamy, S.,Druzina, Z.,Ho, C.,Kang, N.R.,Pustilnik, A.,Wang, J.,Atwell, S.; Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing.; Plos One, 15:e0232311-e0232311, 2020; PubMed: 32915778; DOI: 10.1371/journal.pone.0232311

Experimental method

X-RAY DIFFRACTION (2.82 Å)