6WGL

Dupilumab fab with Crystal Kappa design complexed with human IL-4 receptor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dupilumab Fab heavy chain	polymer	234	25233.1	1		Homo sapiens (human)
2	B (B)	Dupilumab Fab light chain	polymer	217	23809.5	1		Homo sapiens (human)
3	C (C)	Interleukin-4 receptor subunit alpha	polymer	218	24908.8	1	UniProt (P24394) Pfam (PF09238)	Homo sapiens (Human)	IL-4RA
4	D, E (D, E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	F (C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
6	G, H, I (A, B, C)	water	water		18.0	26	Chemie (HOH)

Sequence modifications

C: 1 - 207 (UniProt: P24394)

PDB	External Database	Details
Leu 182	Cys 207	conflict
Gly 208	-	expression tag
Gly 209	-	expression tag
Gly 210	-	expression tag
Gly 211	-	expression tag
Ser 212	-	expression tag
His 213	-	expression tag
His 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	73951.4
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	75021.4

*Water molecules are not included.