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3C4X
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BU of 3c4x by Molmil
Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.9A
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Singh, P, Tesmer, J.J.G.
Deposit date:2008-01-30
Release date:2008-03-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
J.Biol.Chem., 283, 2008
5HE2
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BU of 5he2 by Molmil
Bovine GRK2 in complex with Gbetagamma subunits and CCG224406
Descriptor: (4~{S})-4-[3-[(2,6-dimethoxyphenyl)methylcarbamoyl]-4-fluoranyl-phenyl]-~{N}-(1~{H}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-pyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cato, M.C, Waninger-Saroni, J, Tesmer, J.J.G.
Deposit date:2016-01-05
Release date:2016-05-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.
J.Med.Chem., 59, 2016
5HE1
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BU of 5he1 by Molmil
Human GRK2 in complex with Gbetagamma subunits and CCG224062
Descriptor: (4~{S})-4-[4-fluoranyl-3-(isoquinolin-1-ylmethylcarbamoyl)phenyl]-~{N}-(1~{H}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-pyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cato, M.C, Tesmer, J.J.G.
Deposit date:2016-01-05
Release date:2016-05-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.
J.Med.Chem., 59, 2016
6D8Z
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BU of 6d8z by Molmil
Crystal Structure of the C-terminal Guanine Nucleotide Exchange Factor Module of Human Trio
Descriptor: Triple functional domain protein
Authors:Bandekar, S, Tesmer, J.J.
Deposit date:2018-04-27
Release date:2019-02-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential.
Sci Signal, 12, 2019
5HE0
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BU of 5he0 by Molmil
Bovine GRK2 in complex with Gbetagamma subunits and CCG215022
Descriptor: (4S)-4-{4-fluoro-3-[(pyridin-2-ylmethyl)carbamoyl]phenyl}-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cato, M.C, Waninger-Saroni, J, Tesmer, J.J.G.
Deposit date:2016-01-05
Release date:2016-05-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.
J.Med.Chem., 59, 2016
5HE3
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BU of 5he3 by Molmil
Bovine GRK2 in complex with Gbetagamma subunits and CCG224411
Descriptor: (4~{S})-4-[3-[2-(2,6-dimethylphenyl)ethylcarbamoyl]-4-fluoranyl-phenyl]-~{N}-(1~{H}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-pyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cato, M.C, Tesmer, J.J.G.
Deposit date:2016-01-05
Release date:2016-05-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors.
J.Med.Chem., 59, 2016
5FI1
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BU of 5fi1 by Molmil
Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42
Descriptor: Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Authors:Cash, J.N, Tesmer, J.J.G.
Deposit date:2015-12-22
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.203 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5FI0
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BU of 5fi0 by Molmil
Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1
Descriptor: PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein, Ras-related C3 botulinum toxin substrate 1
Authors:Cash, J.N, Tesmer, J.J.G.
Deposit date:2015-12-22
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.282 Å)
Cite:Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
5UKL
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BU of 5ukl by Molmil
Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd)
Descriptor: 2-{5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluorophenyl}-N-[2-(1H-pyrazol-4-yl)ethyl]acetamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cato, M.C, Homan, K.T, Tesmer, J.J.G.
Deposit date:2017-01-23
Release date:2017-04-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
J. Med. Chem., 60, 2017
5UKM
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BU of 5ukm by Molmil
bovine GRK2 in complex with human Gbetagamma subunits and CCG258208 (14as)
Descriptor: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(1H-pyrazol-5-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cruz-Rodriguez, O, Tesmer, J.J.G.
Deposit date:2017-01-23
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
J. Med. Chem., 60, 2017
5UKK
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BU of 5ukk by Molmil
Human GRK2 in complex with human G-beta-gamma subunits and CCG211998 (14ak)
Descriptor: 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(pyridin-2-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Cato, M.C, Homan, K.T, Tesmer, J.J.G.
Deposit date:2017-01-23
Release date:2017-04-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
J. Med. Chem., 60, 2017
3PUI
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BU of 3pui by Molmil
Cocaine Esterase with mutations G4C, S10C
Descriptor: CHLORIDE ION, Cocaine esterase, SODIUM ION
Authors:Nance, M.R, Tesmer, J.J.G.
Deposit date:2010-12-04
Release date:2011-09-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol.Pharmacol., 80, 2011
3PUH
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BU of 3puh by Molmil
Cocaine Esterase, wild-type biologically active dimer
Descriptor: Cocaine esterase, GLYCEROL, SULFATE ION
Authors:Nance, M.R, Tesmer, J.J.G.
Deposit date:2010-12-04
Release date:2011-09-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
Mol.Pharmacol., 80, 2011
3QC9
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BU of 3qc9 by Molmil
Crystal structure of cross-linked bovine GRK1 T8C/N480C double mutant complexed with ADP and Mg
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Huang, C.-C, Tesmer, J.J.G.
Deposit date:2011-01-15
Release date:2011-02-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase Domain.
Biochemistry, 50, 2011
1APB
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BU of 1apb by Molmil
A PRO TO GLY MUTATION IN THE HINGE OF THE ARABINOSE-BINDING PROTEIN ENHANCES BINDING AND ALTERS SPECIFICITY: SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES
Descriptor: L-ARABINOSE-BINDING PROTEIN, alpha-D-fucopyranose, beta-D-fucopyranose
Authors:Vermersch, P.S, Tesmer, J.J.G, Quiocho, F.A.
Deposit date:1991-11-15
Release date:1992-01-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.
J.Biol.Chem., 265, 1990
1BAP
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BU of 1bap by Molmil
A PRO TO GLY MUTATION IN THE HINGE OF THE ARABINOSE-BINDING PROTEIN ENHANCES BINDING AND ALTERS SPECIFICITY: SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES
Descriptor: L-ARABINOSE-BINDING PROTEIN, alpha-L-arabinopyranose, beta-L-arabinopyranose
Authors:Vermersch, P.S, Tesmer, J.J.G, Quiocho, F.A.
Deposit date:1991-11-15
Release date:1992-01-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.
J.Biol.Chem., 265, 1990
3PSC
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BU of 3psc by Molmil
Bovine GRK2 in complex with Gbetagamma subunits
Descriptor: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Authors:Thal, D.M, Tesmer, J.J.
Deposit date:2010-12-01
Release date:2011-06-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
3PVU
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BU of 3pvu by Molmil
Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101)
Descriptor: 3-({[4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Thal, D.M, Tesmer, J.J.
Deposit date:2010-12-07
Release date:2011-06-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
3PVW
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BU of 3pvw by Molmil
Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD103A)
Descriptor: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Thal, D.M, Tesmer, J.J.
Deposit date:2010-12-07
Release date:2011-06-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
5WG3
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BU of 5wg3 by Molmil
Human GRK2 in complex with Gbetagamma subunits and CCG258748
Descriptor: 2-fluoro-5-[(3S,4R)-3-{[(1H-indazol-5-yl)oxy]methyl}piperidin-4-yl]-N-[(1H-pyrazol-3-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Bouley, R, Tesmer, J.J.G.
Deposit date:2017-07-13
Release date:2017-12-27
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.896 Å)
Cite:Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol. Pharmacol., 92, 2017
6PCV
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BU of 6pcv by Molmil
Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1
Authors:Cash, J.N, Cianfrocco, M.A, Tesmer, J.J.G.
Deposit date:2019-06-18
Release date:2019-10-23
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold.
Sci Adv, 5, 2019
6O5G
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BU of 6o5g by Molmil
Calmodulin in complex with isomalbrancheamide D
Descriptor: (5aS,12aS,13aS)-9-bromo-8-chloro-12,12-dimethyl-2,3,11,12,12a,13-hexahydro-1H,5H,6H-5a,13a-(epiminomethano)indolizino[7 ,6-b]carbazol-14-one, CALCIUM ION, Calmodulin-1, ...
Authors:Beyett, T.S, Fraley, A.E, Tesmer, J.J.G.
Deposit date:2019-03-02
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe.
Proc.Natl.Acad.Sci.USA, 116, 2019
6MTW
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BU of 6mtw by Molmil
Lysosomal Phospholipase A2 in complex with Zinc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Group XV phospholipase A2, ...
Authors:Bouley, R, Tesmer, J.J.G.
Deposit date:2018-10-22
Release date:2019-03-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Structural Basis of Lysosomal Phospholipase A2Inhibition by Zn2.
Biochemistry, 58, 2019
7MTB
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BU of 7mtb by Molmil
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin and Fab6
Descriptor: Fab6 heavy chain, Fab6 light chain, RETINAL, ...
Authors:Chen, Q, Chen, C.-L, Tesmer, J.J.G.
Deposit date:2021-05-13
Release date:2021-07-07
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021
7MT8
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BU of 7mt8 by Molmil
Rhodopsin kinase (GRK1)-S5E/S488E/T489E in complex with rhodopsin
Descriptor: RETINAL, Rhodopsin, Rhodopsin kinase GRK1, ...
Authors:Chen, Q, Chen, C.-L, Tesmer, J.J.G.
Deposit date:2021-05-13
Release date:2021-07-07
Last modified:2021-08-25
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Nature, 595, 2021

222036

數據於2024-07-03公開中

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