5HE1

Human GRK2 in complex with Gbetagamma subunits and CCG224062

Summary for 5HE1

Entry DOI	10.2210/pdb5he1/pdb
Related	5HE0 5HE2 5HE3
Descriptor	Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	rgs, kinase, ph, wd-40, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	120494.58
Authors	Cato, M.C.,Tesmer, J.J.G. (deposition date: 2016-01-05, release date: 2016-05-11, Last modification date: 2024-03-06)
Primary citation	Waldschmidt, H.V.,Homan, K.T.,Cruz-Rodriguez, O.,Cato, M.C.,Waninger-Saroni, J.,Larimore, K.M.,Cannavo, A.,Song, J.,Cheung, J.Y.,Kirchhoff, P.D.,Koch, W.J.,Tesmer, J.J.,Larsen, S.D. Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J.Med.Chem., 59:3793-3807, 2016 Cited by PubMed: 27050625 DOI: 10.1021/acs.jmedchem.5b02000 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.15 Å)

Structure validation