5HE1
Human GRK2 in complex with Gbetagamma subunits and CCG224062
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-adrenergic receptor kinase 1 | polymer | 642 | 74789.9 | 1 | UniProt (P25098) Pfam (PF00615) Pfam (PF00069) Pfam (PF00169) | Homo sapiens (Human) | Beta-ARK-1, G-protein coupled receptor kinase 2 |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7845.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 4 | D (A) | (4~{S})-4-[4-fluoranyl-3-(isoquinolin-1-ylmethylcarbamoyl)phenyl]-~{N}-(1~{H}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-pyrimidine-5-carboxamide | non-polymer | 549.6 | 1 | Chemie (ZS2) | |||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
A: 29 - 670 (UniProt: P25098)
G: 1 - 71 (UniProt: P59768)
| PDB | External Database | Details |
|---|---|---|
| Ala 670 | Ser 670 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 68 | Cys 68 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 119920.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 573.9 | |
| All* | Total formula weight | 120494.6 |
