6PCV

Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits

Summary for 6PCV

• Entry DOI: 10.2210/pdb6pcv/pdb
• EMDB information: 20308
• Descriptor: Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (3 entities in total)
• Functional Keywords: rhogef, g protein, complex, phosphatase fold, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 231484.37

Authors

Cash, J.N.,Cianfrocco, M.A.,Tesmer, J.J.G. (deposition date: 2019-06-18, release date: 2019-10-23, Last modification date: 2024-03-20)

• Primary citation: Cash, J.N.,Urata, S.,Li, S.,Ravala, S.K.,Avramova, L.V.,Shost, M.D.,Gutkind, J.S.,Tesmer, J.J.G.,Cianfrocco, M.A.; Cryo-electron microscopy structure and analysis of the P-Rex1-G beta gamma signaling scaffold.; Sci Adv, 5:eaax8855-eaax8855, 2019; PubMed: 31663027; DOI: 10.1126/sciadv.aax8855

Experimental method

ELECTRON MICROSCOPY (3.2 Å)