6PCV
Single Particle Reconstruction of Phosphatidylinositol (3,4,5) trisphosphate-dependent Rac exchanger 1 bound to G protein beta gamma subunits
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006801 | biological_process | superoxide metabolic process |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0030041 | biological_process | actin filament polymerization |
| A | 0030291 | molecular_function | protein serine/threonine kinase inhibitor activity |
| A | 0030335 | biological_process | positive regulation of cell migration |
| A | 0030426 | cellular_component | growth cone |
| A | 0030833 | biological_process | regulation of actin filament polymerization |
| A | 0032007 | biological_process | negative regulation of TOR signaling |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0042119 | biological_process | neutrophil activation |
| A | 0043198 | cellular_component | dendritic shaft |
| A | 0045321 | biological_process | leukocyte activation |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050773 | biological_process | regulation of dendrite development |
| A | 0051056 | biological_process | regulation of small GTPase mediated signal transduction |
| A | 0072593 | biological_process | reactive oxygen species metabolic process |
| B | 0001750 | cellular_component | photoreceptor outer segment |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005834 | cellular_component | heterotrimeric G-protein complex |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| B | 0016020 | cellular_component | membrane |
| B | 0030159 | molecular_function | signaling receptor complex adaptor activity |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045202 | cellular_component | synapse |
| B | 0051020 | molecular_function | GTPase binding |
| B | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| B | 0071870 | biological_process | cellular response to catecholamine stimulus |
| B | 0097381 | cellular_component | photoreceptor disc membrane |
| G | 0003924 | molecular_function | GTPase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005834 | cellular_component | heterotrimeric G-protein complex |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0007165 | biological_process | signal transduction |
| G | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| G | 0007191 | biological_process | adenylate cyclase-activating dopamine receptor signaling pathway |
| G | 0016020 | cellular_component | membrane |
| G | 0031681 | molecular_function | G-protein beta-subunit binding |
| G | 0071380 | biological_process | cellular response to prostaglandin E stimulus |
| G | 0071870 | biological_process | cellular response to catecholamine stimulus |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS |
| Chain | Residue | Details |
| B | LEU70-SER84 | |
| B | ILE157-ILE171 | |
| B | LEU285-ALA299 |
| site_id | PS00741 |
| Number of Residues | 26 |
| Details | DH_1 Dbl homology (DH) domain signature. LegYLlsPIqrIcKypLlLkELakrT |
| Chain | Residue | Details |
| A | LEU188-THR213 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI3 |
| Number of Residues | 74 |
| Details | Domain: {"description":"DEP 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00066","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 78 |
| Details | Domain: {"description":"PDZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 48 |
| Details | Repeat: {"description":"WD 1","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 45 |
| Details | Repeat: {"description":"WD 2","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"WD 3","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 4","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 43 |
| Details | Repeat: {"description":"WD 5","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"WD 6","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 30 |
| Details | Repeat: {"description":"WD 7","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P62873","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"PubMed","id":"12486123","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
