4IAQ
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![BU of 4iaq by Molmil](/molmil-images/mine/4iaq) | Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with dihydroergotamine (PSI Community Target) | Descriptor: | Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Dihydroergotamine | Authors: | Wang, C, Jiang, Y, Ma, J, Wu, H, Wacker, D, Katritch, V, Han, G.W, Liu, W, Huang, X, Vardy, E, McCorvy, J.D, Gao, X, Zhou, E.X, Melcher, K, Zhang, C, Bai, F, Yang, H, Yang, L, Jiang, H, Roth, B.L, Cherezov, V, Stevens, R.C, Xu, H.E, GPCR Network (GPCR) | Deposit date: | 2012-12-07 | Release date: | 2013-03-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for molecular recognition at serotonin receptors. Science, 340, 2013
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4PDL
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![BU of 4pdl by Molmil](/molmil-images/mine/4pdl) | Structure of K+ selective NaK mutant in caesium | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CESIUM ION, HEXANE, ... | Authors: | Lam, Y, Zeng, W, Sauer, D.B, Jiang, Y. | Deposit date: | 2014-04-19 | Release date: | 2014-07-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | High Resolution Structural Views of Rubidium, Cesium and Barium Binding within a Potassium Selective Channel Filter To Be Published
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6CMO
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![BU of 6cmo by Molmil](/molmil-images/mine/6cmo) | Rhodopsin-Gi complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy chain, Fab light chain, ... | Authors: | Kang, Y, Kuybeda, O, de Waal, P.W, Mukherjee, S, Van Eps, N, Dutka, P, Zhou, X.E, Bartesaghi, A, Erramilli, S, Morizumi, T, Gu, X, Yin, Y, Liu, P, Jiang, Y, Meng, X, Zhao, G, Melcher, K, Earnst, O.P, Kossiakoff, A.A, Subramaniam, S, Xu, H.E. | Deposit date: | 2018-03-05 | Release date: | 2018-06-20 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature, 558, 2018
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4IAR
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![BU of 4iar by Molmil](/molmil-images/mine/4iar) | Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with ergotamine (PSI Community Target) | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Ergotamine | Authors: | Wang, C, Jiang, Y, Ma, J, Wu, H, Wacker, D, Katritch, V, Han, G.W, Liu, W, Huang, X, Vardy, E, McCorvy, J.D, Gao, X, Zhou, E.X, Melcher, K, Zhang, C, Bai, F, Yang, H, Yang, L, Jiang, H, Roth, B.L, Cherezov, V, Stevens, R.C, Xu, H.E, GPCR Network (GPCR) | Deposit date: | 2012-12-07 | Release date: | 2013-03-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for molecular recognition at serotonin receptors. Science, 340, 2013
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8IX3
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![BU of 8ix3 by Molmil](/molmil-images/mine/8ix3) | Cryo-EM structure of SARS-CoV-2 BA.4/5 spike protein in complex with 1G11 (local refinement) | Descriptor: | BA.4/5 variant spike protein, heavy chain of 1G11, light chain of 1G11 | Authors: | Sun, H, Jiang, Y, Zheng, Z, Zheng, Q, Li, S. | Deposit date: | 2023-03-31 | Release date: | 2023-11-15 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.98 Å) | Cite: | Structural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant. J.Virol., 97, 2023
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8IRV
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![BU of 8irv by Molmil](/molmil-images/mine/8irv) | Dopamine Receptor D5R-Gs-Rotigotine complex | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | Deposit date: | 2023-03-19 | Release date: | 2023-06-07 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural genomics of the human dopamine receptor system. Cell Res., 33, 2023
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8IRT
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![BU of 8irt by Molmil](/molmil-images/mine/8irt) | Dopamine Receptor D3R-Gi-Rotigotine complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | Deposit date: | 2023-03-19 | Release date: | 2023-06-07 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Structural genomics of the human dopamine receptor system. Cell Res., 33, 2023
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8IRS
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![BU of 8irs by Molmil](/molmil-images/mine/8irs) | Dopamine Receptor D2R-Gi-Rotigotine complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | Deposit date: | 2023-03-19 | Release date: | 2023-06-07 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural genomics of the human dopamine receptor system. Cell Res., 33, 2023
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8IRR
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![BU of 8irr by Molmil](/molmil-images/mine/8irr) | Dopamine Receptor D1R-Gs-Rotigotine complex | Descriptor: | CHOLESTEROL, D(1A) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | Deposit date: | 2023-03-19 | Release date: | 2023-06-21 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural genomics of the human dopamine receptor system. Cell Res., 33, 2023
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8IRU
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![BU of 8iru by Molmil](/molmil-images/mine/8iru) | Dopamine Receptor D4R-Gi-Rotigotine complex | Descriptor: | CHOLESTEROL, D(4) dopamine receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E. | Deposit date: | 2023-03-19 | Release date: | 2023-06-21 | Last modified: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural genomics of the human dopamine receptor system. Cell Res., 33, 2023
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1AIP
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![BU of 1aip by Molmil](/molmil-images/mine/1aip) | EF-TU EF-TS COMPLEX FROM THERMUS THERMOPHILUS | Descriptor: | ELONGATION FACTOR TS, ELONGATION FACTOR TU | Authors: | Wang, Y, Jiang, Y, Meyering-Voss, M, Sprinzl, M, Sigler, P.B. | Deposit date: | 1997-04-22 | Release date: | 1997-10-22 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the EF-Tu.EF-Ts complex from Thermus thermophilus. Nat.Struct.Biol., 4, 1997
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8X7A
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![BU of 8x7a by Molmil](/molmil-images/mine/8x7a) | Treprostinil bound Prostacyclin Receptor G protein complex | Descriptor: | 2-[[(1~{R},2~{R},3~{a}~{S},9~{a}~{S})-2-oxidanyl-1-[(3~{S})-3-oxidanyloctyl]-2,3,3~{a},4,9,9~{a}-hexahydro-1~{H}-cyclopenta[g]naphthalen-5-yl]oxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, J.J, Jin, S, Zhang, H, Xu, Y, Hu, W, Jiang, Y, Chen, C, Wang, D.W, Xu, H.E, Wu, C. | Deposit date: | 2023-11-23 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.56 Å) | Cite: | Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs. Sci Adv, 10, 2024
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8X79
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![BU of 8x79 by Molmil](/molmil-images/mine/8x79) | MRE-269 bound Prostacyclin Receptor G protein complex | Descriptor: | 2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-yl-amino]butoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Wang, J.J, Jin, S, Zhang, H, Xu, Y, Hu, W, Jiang, Y, Chen, C, Wang, D.W, Xu, H.E, Wu, C. | Deposit date: | 2023-11-23 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.41 Å) | Cite: | Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs. Sci Adv, 10, 2024
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5Z4A
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![BU of 5z4a by Molmil](/molmil-images/mine/5z4a) | Structure of Tailor in complex with AGU RNA | Descriptor: | RNA (5'-R(*AP*GP*U)-3'), Terminal uridylyltransferase Tailor | Authors: | Cheng, L, Li, F, Jiang, Y, Yu, H, Xie, C, Shi, Y, Gong, Q. | Deposit date: | 2018-01-10 | Release date: | 2018-10-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.637 Å) | Cite: | Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor. Nucleic Acids Res., 47, 2019
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5ZXD
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![BU of 5zxd by Molmil](/molmil-images/mine/5zxd) | Crystal structure of ATP-bound human ABCF1 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family F member 1 | Authors: | Qu, L, Jiang, Y, Liu, Z.J. | Deposit date: | 2018-05-18 | Release date: | 2018-07-25 | Last modified: | 2018-09-19 | Method: | X-RAY DIFFRACTION (2.288 Å) | Cite: | Crystal Structure of ATP-Bound Human ABCF1 Demonstrates a Unique Conformation of ABC Proteins Structure, 26, 2018
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3OUS
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![BU of 3ous by Molmil](/molmil-images/mine/3ous) | MthK channel pore T59A mutant | Descriptor: | Calcium-gated potassium channel mthK, POTASSIUM ION | Authors: | Derebe, M.G, Sauer, D.B, Zeng, W, Alam, A, Shi, N, Jiang, Y. | Deposit date: | 2010-09-15 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites. Proc.Natl.Acad.Sci.USA, 108, 2011
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5TUA
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![BU of 5tua by Molmil](/molmil-images/mine/5tua) | structure of a Na+-selective mutant of two-pore channel from Arabidopsis thaliana AtTPC1 | Descriptor: | BARIUM ION, CALCIUM ION, SODIUM ION, ... | Authors: | Guo, J, Zeng, W, Jiang, Y. | Deposit date: | 2016-11-05 | Release date: | 2017-01-18 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Tuning the ion selectivity of two-pore channels. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5VRE
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![BU of 5vre by Molmil](/molmil-images/mine/5vre) | |
3OUF
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![BU of 3ouf by Molmil](/molmil-images/mine/3ouf) | Structure of a K+ selective NaK mutant | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein | Authors: | Derebe, M.G, Sauer, D.B, Zeng, W, Alam, A, Shi, N, Jiang, Y. | Deposit date: | 2010-09-14 | Release date: | 2011-01-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites. Proc.Natl.Acad.Sci.USA, 108, 2011
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4IB4
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![BU of 4ib4 by Molmil](/molmil-images/mine/4ib4) | Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, ... | Authors: | Wacker, D, Wang, C, Katritch, V, Han, G.W, Huang, X, Vardy, E, McCorvy, J.D, Jiang, Y, Chu, M, Siu, F.Y, Liu, W, Xu, H.E, Cherezov, V, Roth, B.L, Stevens, R.C, GPCR Network (GPCR) | Deposit date: | 2012-12-07 | Release date: | 2013-03-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural features for functional selectivity at serotonin receptors. Science, 340, 2013
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6NBI
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![BU of 6nbi by Molmil](/molmil-images/mine/6nbi) | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein | Descriptor: | CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. | Deposit date: | 2018-12-07 | Release date: | 2019-04-17 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure and dynamics of the active human parathyroid hormone receptor-1. Science, 364, 2019
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6NBH
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![BU of 6nbh by Molmil](/molmil-images/mine/6nbh) | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein | Descriptor: | CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. | Deposit date: | 2018-12-07 | Release date: | 2019-04-17 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure and dynamics of the active human parathyroid hormone receptor-1. Science, 364, 2019
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7WQ4
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![BU of 7wq4 by Molmil](/molmil-images/mine/7wq4) | Galanin-bound galanin receptor 2 in complex with Gq | Descriptor: | CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Galanin, ... | Authors: | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | Deposit date: | 2022-01-24 | Release date: | 2022-04-20 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
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7WQ3
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![BU of 7wq3 by Molmil](/molmil-images/mine/7wq3) | Galanin-bound galanin receptor 1 in complex with Gi | Descriptor: | CHOLESTEROL, Galanin, Galanin receptor type 1, ... | Authors: | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | Deposit date: | 2022-01-24 | Release date: | 2022-04-20 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
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8J40
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![BU of 8j40 by Molmil](/molmil-images/mine/8j40) | Crystal Structure of CATB8 in complex with chloramphenicol | Descriptor: | CHLORAMPHENICOL, CatB8, GLYCEROL, ... | Authors: | Liao, J, Kuang, L, Jiang, Y. | Deposit date: | 2023-04-18 | Release date: | 2024-02-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Chloramphenicol Binding Sites of Acinetobacter baumannii Chloramphenicol Acetyltransferase CatB8. Acs Infect Dis., 10, 2024
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