8IX3

Cryo-EM structure of SARS-CoV-2 BA.4/5 spike protein in complex with 1G11 (local refinement)

Summary for 8IX3

• Entry DOI: 10.2210/pdb8ix3/pdb
• EMDB information: 35788
• Descriptor: light chain of 1G11, heavy chain of 1G11, BA.4/5 variant spike protein (3 entities in total)
• Functional Keywords: sars-cov-2, neutralizing antibody, cryo-em, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 49351.15

Authors

Sun, H.,Jiang, Y.,Zheng, Z.,Zheng, Q.,Li, S. (deposition date: 2023-03-31, release date: 2023-11-15, Last modification date: 2024-11-20)

Primary citation

Sun, H.,Wang, Y.,Chen, X.,Jiang, Y.,Wang, S.,Huang, Y.,Liu, L.,Li, Y.,Lan, M.,Guo, H.,Yuan, Q.,Zhang, Y.,Li, T.,Yu, H.,Gu, Y.,Zhang, J.,Li, S.,Zheng, Z.,Zheng, Q.,Xia, N.
Structural basis for broad neutralization of human antibody against Omicron sublineages and evasion by XBB variant.
J.Virol., 97:e0113723-e0113723, 2023

PubMed Abstract: The ongoing COVID-19 pandemic has been characterized by the emergence of new SARS-CoV-2 variants including the highly transmissible Omicron XBB sublineages, which have shown significant resistance to neutralizing antibodies (nAbs). This resistance has led to decreased vaccine effectiveness and therefore result in breakthrough infections and reinfections, which continuously threaten public health. To date, almost all available therapeutic nAbs, including those authorized under Emergency Use Authorization nAbs that were previously clinically useful against early strains, have recently been found to be ineffective against newly emerging variants. In this study, we provide a comprehensive structural basis about how the Class 3 nAbs, including 1G11 in this study and noted LY-CoV1404, are evaded by the newly emerged SARS-CoV-2 variants.

PubMed: 37855619
DOI: 10.1128/jvi.01137-23

Experimental method

ELECTRON MICROSCOPY (3.98 Å)