8IRU
Dopamine Receptor D4R-Gi-Rotigotine complex
Summary for 8IRU
Entry DOI | 10.2210/pdb8iru/pdb |
EMDB information | 35686 |
Descriptor | Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ScFv16, ... (7 entities in total) |
Functional Keywords | dopamine, dopamine receptor, gpcr, d4r, gi, rotigotine, polypharmacology parkinson's disease, restless legs syndrome, membrane protein |
Biological source | Homo sapiens More |
Total number of polymer chains | 5 |
Total formula weight | 203559.77 |
Authors | |
Primary citation | Xu, P.,Huang, S.,Krumm, B.E.,Zhuang, Y.,Mao, C.,Zhang, Y.,Wang, Y.,Huang, X.P.,Liu, Y.F.,He, X.,Li, H.,Yin, W.,Jiang, Y.,Zhang, Y.,Roth, B.L.,Xu, H.E. Structural genomics of the human dopamine receptor system. Cell Res., 33:604-616, 2023 Cited by PubMed: 37221270DOI: 10.1038/s41422-023-00808-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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