8IRU

Dopamine Receptor D4R-Gi-Rotigotine complex

Summary for 8IRU

Entry DOI	10.2210/pdb8iru/pdb
EMDB information	35686
Descriptor	Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ScFv16, ... (7 entities in total)
Functional Keywords	dopamine, dopamine receptor, gpcr, d4r, gi, rotigotine, polypharmacology parkinson's disease, restless legs syndrome, membrane protein
Biological source	Homo sapiens More
Total number of polymer chains	5
Total formula weight	203559.77
Authors	Xu, P.,Huang, S.,Zhuang, Y.,Mao, C.,Zhang, Y.,Wang, Y.,Li, H.,Jiang, Y.,Zhang, Y.,Xu, H.E. (deposition date: 2023-03-19, release date: 2023-06-21, Last modification date: 2023-11-08)
Primary citation	Xu, P.,Huang, S.,Krumm, B.E.,Zhuang, Y.,Mao, C.,Zhang, Y.,Wang, Y.,Huang, X.P.,Liu, Y.F.,He, X.,Li, H.,Yin, W.,Jiang, Y.,Zhang, Y.,Roth, B.L.,Xu, H.E. Structural genomics of the human dopamine receptor system. Cell Res., 33:604-616, 2023 Cited by PubMed: 37221270 DOI: 10.1038/s41422-023-00808-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation