8IRU
Dopamine Receptor D4R-Gi-Rotigotine complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 361 | 41641.2 | 1 | Homo sapiens | ||
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 371 | 40243.9 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | |
| 3 | C (E) | ScFv16 | polymer | 248 | 26466.5 | 1 | Mus musculus | ||
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E (R) | D(4) dopamine receptor | polymer | 785 | 83551.7 | 1 | Homo sapiens | ||
| 6 | F (R) | Rotigotine | non-polymer | 315.5 | 1 | Chemie (R5F) | |||
| 7 | G, H, I, J, K... (R) | CHOLESTEROL | non-polymer | 386.7 | 9 | Chemie (CLR) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Ser 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Val 356 | - | expression tag |
| Thr 357 | - | expression tag |
| Gly 358 | - | expression tag |
| Tyr 359 | - | expression tag |
| Arg 360 | - | expression tag |
| Leu 361 | - | expression tag |
| Phe 362 | - | expression tag |
| Glu 363 | - | expression tag |
| Glu 364 | - | expression tag |
| Ile 365 | - | expression tag |
| Leu 366 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 199764.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3795.4 | |
| All* | Total formula weight | 203559.8 |
