7S2R
 
 | | nanobody bound to IL-2Rg | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | | 著者 | Glassman, C.R, Jude, K.M, Yen, M, Garcia, K.C. | | 登録日 | 2021-09-03 | | 公開日 | 2022-03-30 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Facile discovery of surrogate cytokine agonists.
Cell, 185, 2022
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7S2S
 | | nanobody bound to Interleukin-2Rbeta | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, IL2Rb-binding nanobody, Interleukin-2 receptor subunit beta, ... | | 著者 | Glassman, C.R, Jude, K.M, Yen, M, Garcia, K.C. | | 登録日 | 2021-09-03 | | 公開日 | 2022-03-30 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Facile discovery of surrogate cytokine agonists.
Cell, 185, 2022
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4WV3
 | | Crystal structure of the anthranilate CoA ligase AuaEII in complex with anthranoyl-AMP | | 分子名称: | 5'-O-[(S)-[(2-aminobenzoyl)oxy](hydroxy)phosphoryl]adenosine, Anthranilate-CoA ligase | | 著者 | Tsai, S.C, Muller, R, Jackson, D.R, Tu, S.S, Nguyen, M, Barajas, J.F, Pistorious, D, Krug, D. | | 登録日 | 2014-11-04 | | 公開日 | 2015-11-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.599 Å) | | 主引用文献 | Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis.
Acs Chem.Biol., 11, 2016
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8OPI
 | | VHH Z70 mutant 1 in interaction with PHF6 Tau peptide | | 分子名称: | PHF6 Tau peptide, VHH Z70 mutant 1 | | 著者 | Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I. | | 登録日 | 2023-04-07 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.
J.Biol.Chem., 300, 2024
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8OP0
 | | VHH Z70 mutant 20 in interaction with PHF6 Tau peptide | | 分子名称: | Tau PHF6 peptide, VHH Z70 mutant 20 | | 著者 | Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I. | | 登録日 | 2023-04-06 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.
J.Biol.Chem., 300, 2024
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8PII
 | | VHH Z70 mutant 3 in interaction with PHF6 Tau peptide | | 分子名称: | Microtubule-associated protein tau, VHH Z70 Mutant 3 | | 著者 | Dupre, E, Mortelecque, J, NGuyen, M, Hanoulle, X, Landrieu, I. | | 登録日 | 2023-06-21 | | 公開日 | 2023-07-05 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.
J.Biol.Chem., 300, 2024
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1N2Y
 | | SOLUTION STRUCTURE OF SS-CYCLIZED CATESTATIN FRAGMENT FROM CHROMOGRANIN A | | 分子名称: | CATESTATIN | | 著者 | Preece, N.E, Nguyen, M, Mahata, M, Mahata, S.K, Mahapatra, N.R, Tsigelny, I, O'Connor, D.T. | | 登録日 | 2002-10-24 | | 公開日 | 2002-11-13 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Conformational preferences and activities of peptides from the catecholamine
release-inhibitory (catestatin) region of chromogranin A
Regul.Pept., 118, 2004
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1MRN
 | | CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH BISUBSTRATE INHIBITOR (TP5A) | | 分子名称: | MAGNESIUM ION, P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, SULFATE ION, ... | | 著者 | Haouz, A, Vanheusden, V, Munier-Lehmann, H, Froeyen, M, Herdewijn, P, Van Calenbergh, S, Delarue, M. | | 登録日 | 2002-09-18 | | 公開日 | 2003-01-07 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
J.Biol.Chem., 278, 2003
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3J4B
 | | Structure of T7 gatekeeper protein (gp11) | | 分子名称: | Tail tubular protein A | | 著者 | Cuervo, A, Pulido-Cid, M, Chagoyen, M, Arranz, R, Gonzalez-Garcia, V.A, Garcia-Doval, C, Caston, J.R, Valpuesta, J.M, van Raaij, M.J, Martin-Benito, J, Carrascosa, J.L. | | 登録日 | 2013-07-09 | | 公開日 | 2013-08-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (12 Å) | | 主引用文献 | Structural characterization of the bacteriophage t7 tail machinery.
J.Biol.Chem., 288, 2013
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4XRT
 | | Crystal structure of the di-domain ARO/CYC StfQ from the steffimycin biosynthetic pathway | | 分子名称: | FORMIC ACID, StfQ Aromatase/Cyclase | | 著者 | Tsai, S.C, Caldara-Festin, G.M, Jackson, D.R, Aguilar, S, Patel, A, Nguyen, M, Sasaki, E, Valentic, T.R, Barajas, J.F, Vo, M, Khanna, A, Liu, H.-W. | | 登録日 | 2015-01-21 | | 公開日 | 2015-12-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.952 Å) | | 主引用文献 | Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4XRW
 | | Crystal structure of the di-domain ARO/CYC BexL from the BE-7585A biosynthetic pathway | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BexL | | 著者 | Tsai, S.C, Caldara-Festin, G.M, Jackson, D.R, Aguilar, S, Patel, A, Nguyen, M, Sasaki, E, Valentic, T.R, Barajas, J.F, Vo, M, Khanna, A, Liu, H.-W. | | 登録日 | 2015-01-21 | | 公開日 | 2015-12-02 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4PDW
 | | A benzonitrile analogue inhibits rhinovirus replication | | 分子名称: | 4-[(4,5-dimethoxy-2-nitrophenyl)acetyl]benzonitrile, Capsid protein VP4/VP2, GLYCEROL, ... | | 著者 | Querol-Audi, J, Guerra, P, Lacroix, C, Roche, M, Franco, D, Froeyen, M, Terme, T, Vanelle, P, Neyts, J, Leyssen, P, Verdaguer, N. | | 登録日 | 2014-04-22 | | 公開日 | 2014-07-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A novel benzonitrile analogue inhibits rhinovirus replication.
J.Antimicrob.Chemother., 69, 2014
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3HPN
 | | Ligand recognition by A-class EPH receptors: crystal structures of the EPHA2 ligand-binding domain and the EPHA2/EPHRIN-A1 complex | | 分子名称: | Ephrin type-A receptor 2 | | 著者 | Himanen, J.P, Goldgur, Y, Miao, H, Myshkin, E, Guo, H, Buck, M, Nguyen, M, Rajashankar, K.R, Wang, B, Nikolov, D.B. | | 登録日 | 2009-06-04 | | 公開日 | 2009-06-30 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | | 主引用文献 | Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10, 2009
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1MRS
 | | CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH 5-CH2OH DEOXYURIDINE MONOPHOSPHATE | | 分子名称: | 5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE, MAGNESIUM ION, SULFATE ION, ... | | 著者 | Haouz, A, Vanheusden, V, Munier-Lehmann, H, Froeyen, M, Herdewijn, P, Van Calenbergh, S, Delarue, M. | | 登録日 | 2002-09-18 | | 公開日 | 2003-01-07 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
J.Biol.Chem., 278, 2003
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3HEI
 | | Ligand Recognition by A-Class Eph Receptors: Crystal Structures of the EphA2 Ligand-Binding Domain and the EphA2/ephrin-A1 Complex | | 分子名称: | Ephrin type-A receptor 2, Ephrin-A1 | | 著者 | Himanen, J.P, Goldgur, Y, Miao, H, Myshkin, E, Guo, H, Buck, M, Nguyen, M, Rajashankar, K.R, Wang, B, Nikolov, D.B. | | 登録日 | 2009-05-08 | | 公開日 | 2009-06-30 | | 最終更新日 | 2021-03-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10, 2009
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3J4A
 | | Structure of gp8 connector protein | | 分子名称: | Head-to-tail joining protein | | 著者 | Cuervo, A, Pulido-Cid, M, Chagoyen, M, Arranz, R, Gonzalez-Garcia, V.A, Garcia-Doval, C, Caston, J.R, Valpuesta, J.M, van Raaij, M.J, Martin-Benito, J, Carrascosa, J.L. | | 登録日 | 2013-07-09 | | 公開日 | 2013-08-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (12 Å) | | 主引用文献 | Structural characterization of the bacteriophage t7 tail machinery.
J.Biol.Chem., 288, 2013
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1QXB
 | | NMR structure determination of the self complementary DNA Dodecamer CGCGAATT*CGCG in which a ribose is inserted between the 3'-OH of T8 and the 5'-phosphate group of C9 | | 分子名称: | 5'-d(CpGpCpGpApApTpTpCpGpCpG)-3', beta-D-ribofuranose | | 著者 | Nauwelaerts, K, Vastmans, K, Froeyen, M, Kempeneers, V, Rozenski, J, Rosemeyer, H, Van Aerschot, A, Busson, R, Efimtseva, E, Mikhailov, S, Lescrinier, E, Herdewijn, P. | | 登録日 | 2003-09-05 | | 公開日 | 2004-02-03 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Cleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleoside.
Nucleic Acids Res., 31, 2003
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4YBI
 | | Crystal structure of BACE with amino thiazine inhibitor LY2811376 | | 分子名称: | (4S)-4-[2,4-difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine, Beta-secretase 1, GLYCEROL | | 著者 | Timm, D.E. | | 登録日 | 2015-02-18 | | 公開日 | 2015-04-01 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor.
J.Neurosci., 31, 2011
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7UWL
 | | Structure of the IL-25-IL-17RB-IL-17RA ternary complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | | 著者 | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | | 登録日 | 2022-05-03 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
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7UWM
 | | Structure of the IL-17A-IL-17RA binary complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | | 著者 | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | | 登録日 | 2022-05-03 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
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7UWJ
 | | Structure of the homodimeric IL-25-IL-17RB binary complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor B, Interleukin-25 | | 著者 | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | | 登録日 | 2022-05-03 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
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7UWK
 | | Structure of the higher-order IL-25-IL-17RB complex | | 分子名称: | Interleukin-17 receptor B, Interleukin-25 | | 著者 | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | | 登録日 | 2022-05-03 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | | 主引用文献 | Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
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7UWN
 | | Structure of the IL-17A-IL-17RA-IL-17RC ternary complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ... | | 著者 | Wilson, S.C, Caveney, N.A, Jude, K.M, Garcia, K.C. | | 登録日 | 2022-05-03 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | Organizing structural principles of the IL-17 ligand-receptor axis.
Nature, 609, 2022
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1EQ9
 | | CRYSTAL STRUCTURE OF FIRE ANT CHYMOTRYPSIN COMPLEXED TO PMSF | | 分子名称: | CHYMOTRYPSIN, phenylmethanesulfonic acid | | 著者 | Botos, I, Meyer, E, Nguyen, M.H, Swanson, S.M, Meyer, E.F. | | 登録日 | 2000-04-03 | | 公開日 | 2000-10-03 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The structure of an insect chymotrypsin.
J.Mol.Biol., 298, 2000
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6AX5
 | | RPT1 region of INI1/SNF5/SMARCB1_HUMAN - SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1. | | 分子名称: | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | | 著者 | Girvin, M.E, Cahill, S.M, Harris, R, Cowburn, D, Spira, M, Wu, X, Prakash, R, Bernowitz, M, Almo, S.C, Kalpana, G.V. | | 登録日 | 2017-09-06 | | 公開日 | 2017-10-18 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication.
Nat Commun, 12, 2021
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