3HEI

Ligand Recognition by A-Class Eph Receptors: Crystal Structures of the EphA2 Ligand-Binding Domain and the EphA2/ephrin-A1 Complex

Summary for 3HEI

DescriptorEphrin type-A receptor 2, Ephrin-A1 (3 entities in total)
Functional Keywordseph receptor tyrosine kinase, ephrin, cell membrane, disulfide bond, glycoprotein, gpi-anchor, lipoprotein, membrane, atp-binding, kinase, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase, transferase-signaling protein complex, transferase/signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane ; Single-pass type I membrane protein  P29317
Cell membrane ; Lipid-anchor, GPI-anchor . Ephrin-A1, secreted form: Secreted  P20827
Total number of polymer chains16
Total molecular weight286387.29
Authors
Himanen, J.P.,Goldgur, Y.,Miao, H.,Myshkin, E.,Guo, H.,Buck, M.,Nguyen, M.,Rajashankar, K.R.,Wang, B.,Nikolov, D.B. (deposition date: 2009-05-08, release date: 2009-06-30, Last modification date: 2017-11-01)
Primary citation
Himanen, J.P.,Goldgur, Y.,Miao, H.,Myshkin, E.,Guo, H.,Buck, M.,Nguyen, M.,Rajashankar, K.R.,Wang, B.,Nikolov, D.B.
Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10:722-728, 2009
PubMed: 19525919 (PDB entries with the same primary citation)
DOI: 10.1038/embor.2009.91
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.265141.5%5.6%7.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3hei
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Molmil generated image of 3hei
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Molmil generated image of 3hei
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More Biological unit images

Molmil generated image of 3hei
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Molmil generated image of 3hei
rotated about x axis by 90°
Molmil generated image of 3hei
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3hei.pdb1.gz [63.93 KB])
Coordinate files for Biological unit (3hei.pdb4.gz [64.96 KB])
Coordinate files for Biological unit (3hei.pdb3.gz [63.77 KB])
Coordinate files for Biological unit (3hei.pdb8.gz [61.84 KB])
Coordinate files for Biological unit (3hei.pdb5.gz [62.01 KB])
Coordinate files for Biological unit (3hei.pdb7.gz [63.09 KB])
Coordinate files for Biological unit (3hei.pdb6.gz [62.79 KB])
Coordinate files for Biological unit (3hei.pdb2.gz [64.18 KB])