3HPN

Ligand recognition by A-class EPH receptors: crystal structures of the EPHA2 ligand-binding domain and the EPHA2/EPHRIN-A1 complex

Summary for 3HPN

DescriptorEphrin type-A receptor 2 (2 entities in total)
Functional Keywordseph receptor tyrosine kinase, ephrin, atp-binding, glycoprotein, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein P29317
Total number of polymer chains6
Total molecular weight119481.55
Authors
Himanen, J.P.,Goldgur, Y.,Miao, H.,Myshkin, E.,Guo, H.,Buck, M.,Nguyen, M.,Rajashankar, K.R.,Wang, B.,Nikolov, D.B. (deposition date: 2009-06-04, release date: 2009-06-30, Last modification date: 2011-07-13)
Primary citation
Himanen, J.P.,Goldgur, Y.,Miao, H.,Myshkin, E.,Guo, H.,Buck, M.,Nguyen, M.,Rajashankar, K.R.,Wang, B.,Nikolov, D.B.
Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex.
Embo Rep., 10:722-728, 2009
PubMed: 19525919 (PDB entries with the same primary citation)
DOI: 10.1038/embor.2009.91
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.52 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.319181.2%4.4%4.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3hpn
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Molmil generated image of 3hpn
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Molmil generated image of 3hpn
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More Biological unit images

Molmil generated image of 3hpn
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Molmil generated image of 3hpn
rotated about x axis by 90°
Molmil generated image of 3hpn
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3hpn.pdb1.gz [31.41 KB])
Coordinate files for Biological unit (3hpn.pdb4.gz [31.23 KB])
Coordinate files for Biological unit (3hpn.pdb2.gz [31.76 KB])
Coordinate files for Biological unit (3hpn.pdb9.gz [58.49 KB])
Coordinate files for Biological unit (3hpn.pdb8.gz [58.6 KB])
Coordinate files for Biological unit (3hpn.pdb6.gz [30.79 KB])
Coordinate files for Biological unit (3hpn.pdb5.gz [31.46 KB])
Coordinate files for Biological unit (3hpn.pdb7.gz [59.46 KB])
Coordinate files for Biological unit (3hpn.pdb3.gz [30.86 KB])