4XRT

Crystal structure of the di-domain ARO/CYC StfQ from the steffimycin biosynthetic pathway

Summary for 4XRT

Entry DOI	10.2210/pdb4xrt/pdb
Related	2KF2 2RER 2REZ 3TFZ 4XRW
Descriptor	StfQ Aromatase/Cyclase, FORMIC ACID (3 entities in total)
Functional Keywords	aromatase/cyclase, helix-grip fold, polyketide, polyketide synthase, natural products, dehydratase, aro/cyc, lyase
Biological source	Streptomyces steffisburgensis
Total number of polymer chains	2
Total formula weight	74315.26
Authors	Tsai, S.C.,Caldara-Festin, G.M.,Jackson, D.R.,Aguilar, S.,Patel, A.,Nguyen, M.,Sasaki, E.,Valentic, T.R.,Barajas, J.F.,Vo, M.,Khanna, A.,Liu, H.-W. (deposition date: 2015-01-21, release date: 2015-12-02, Last modification date: 2024-02-28)
Primary citation	Caldara-Festin, G.,Jackson, D.R.,Barajas, J.F.,Valentic, T.R.,Patel, A.B.,Aguilar, S.,Nguyen, M.,Vo, M.,Khanna, A.,Sasaki, E.,Liu, H.W.,Tsai, S.C. Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases. Proc.Natl.Acad.Sci.USA, 112:E6844-E6851, 2015 Cited by PubMed: 26631750 DOI: 10.1073/pnas.1512976112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.952 Å)

Structure validation