2RER
Crystal structure of the aromatase/cyclase domain of TcmN from Streptomyces glaucescens
Summary for 2RER
Entry DOI | 10.2210/pdb2rer/pdb |
Related | 2RES 2REZ |
Descriptor | Multifunctional cyclase-dehydratase-3-O-methyl transferase tcmN (2 entities in total) |
Functional Keywords | cyclase, aromatase, polyketide, helix-grip, dehydratase, anticancer, antibiotic, antibiotic biosynthesis, methyltransferase, multifunctional enzyme, transferase, biosynthetic protein |
Biological source | Streptomyces glaucescens |
Total number of polymer chains | 1 |
Total formula weight | 19938.34 |
Authors | Ames, B.D.,Korman, T.P.,Vu, T.N.,Tsai, S.C. (deposition date: 2007-09-26, release date: 2008-04-22, Last modification date: 2024-02-21) |
Primary citation | Ames, B.D.,Korman, T.P.,Zhang, W.,Smith, P.,Vu, T.,Tang, Y.,Tsai, S.C. Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proc.Natl.Acad.Sci.Usa, 105:5349-5354, 2008 Cited by PubMed: 18388203DOI: 10.1073/pnas.0709223105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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