4YBI
Crystal structure of BACE with amino thiazine inhibitor LY2811376
Summary for 4YBI
Entry DOI | 10.2210/pdb4ybi/pdb |
Related | 4X7I |
Descriptor | Beta-secretase 1, (4S)-4-[2,4-difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine, GLYCEROL, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, aspartyl, protease, beta-secretase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 2 |
Total formula weight | 98949.33 |
Authors | |
Primary citation | May, P.C.,Dean, R.A.,Lowe, S.L.,Martenyi, F.,Sheehan, S.M.,Boggs, L.N.,Monk, S.A.,Mathes, B.M.,Mergott, D.J.,Watson, B.M.,Stout, S.L.,Timm, D.E.,Smith Labell, E.,Gonzales, C.R.,Nakano, M.,Jhee, S.S.,Yen, M.,Ereshefsky, L.,Lindstrom, T.D.,Calligaro, D.O.,Cocke, P.J.,Greg Hall, D.,Friedrich, S.,Citron, M.,Audia, J.E. Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor. J.Neurosci., 31:16507-16516, 2011 Cited by PubMed: 22090477DOI: 10.1523/JNEUROSCI.3647-11.2011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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