Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue 4B2 A 401 |
| Chain | Residue |
| A | GLY11 |
| A | GLY230 |
| A | HOH656 |
| A | HOH775 |
| A | HOH811 |
| A | HOH849 |
| A | GLN12 |
| A | GLY13 |
| A | ASP32 |
| A | TYR71 |
| A | PHE108 |
| A | ILE110 |
| A | TRP115 |
| A | ASP228 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 402 |
| Chain | Residue |
| A | ASP318 |
| A | HOH642 |
| A | HOH739 |
| A | HOH748 |
| B | SER58 |
| B | THR59 |
| B | ARG61 |
| B | ARG96 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | ARG96 |
| A | ASN98 |
| A | GLU134 |
| A | SER139 |
| A | HOH534 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue 4B2 B 401 |
| Chain | Residue |
| B | GLY11 |
| B | GLN12 |
| B | GLY13 |
| B | LEU30 |
| B | ASP32 |
| B | TYR71 |
| B | PHE108 |
| B | ILE110 |
| B | TRP115 |
| B | ILE118 |
| B | ASP228 |
| B | GLY230 |
| B | THR232 |
| B | HOH616 |
| B | HOH726 |
| B | HOH759 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 402 |
| Chain | Residue |
| A | SER58 |
| A | THR59 |
| A | ARG61 |
| A | ARG96 |
| B | ASP318 |
| B | HOH508 |
| B | HOH531 |
| B | HOH735 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| B | ARG96 |
| B | ASN98 |
| B | GLU134 |
| B | GLN143 |
| B | HOH621 |
| B | HOH635 |
| B | HOH823 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE29-VAL40 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17425515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19011241","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 341 |
| Details | Domain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]} |
