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1AXM
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BU of 1axm by Molmil
HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR
分子名称: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ACIDIC FIBROBLAST GROWTH FACTOR
著者DiGabriele, A.D, Lax, I, Chen, D.I, Svahn, C.M, Jaye, M, Schlessinger, J, Hendrickson, W.A.
登録日1997-10-16
公開日1998-04-22
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of a heparin-linked biologically active dimer of fibroblast growth factor.
Nature, 393, 1998
4PGZ
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Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION, Mast/stem cell growth factor receptor Kit
著者Reshetnyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J.
登録日2014-05-03
公開日2015-03-18
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.
Mol.Cell, 57, 2015
3KY2
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BU of 3ky2 by Molmil
Crystal structure of Fibroblast Growth Factor Receptor 1 kinase domain
分子名称: Basic fibroblast growth factor receptor 1, SULFATE ION
著者Bae, J.H, Boggon, T.J, Tome, F, Mandiyan, V, Lax, I, Schlessinger, J.
登録日2009-12-04
公開日2010-03-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Proc.Natl.Acad.Sci.USA, 107, 2010
3KXX
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BU of 3kxx by Molmil
Structure of the mutant Fibroblast Growth Factor receptor 1
分子名称: Basic fibroblast growth factor receptor 1
著者Bae, J.H, Boggon, T.J, Tome, F, Mandiyan, V, Lax, I, Schlessinger, J.
登録日2009-12-04
公開日2010-03-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells.
Proc.Natl.Acad.Sci.USA, 107, 2010
4K94
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BU of 4k94 by Molmil
Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab19 heavy chain, Fab19 light chain, ...
著者Resheynyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J.
登録日2013-04-19
公開日2013-10-16
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proc.Natl.Acad.Sci.USA, 110, 2013
4K9E
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BU of 4k9e by Molmil
Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Mast/stem cell growth factor receptor Kit, heavy chain, ...
著者Resheynyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J.
登録日2013-04-19
公開日2013-10-16
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proc.Natl.Acad.Sci.USA, 110, 2013
3GQL
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BU of 3gql by Molmil
Crystal Structure of activated receptor tyrosine kinase in complex with substrates
分子名称: (E)-[4-(3,5-difluorophenyl)-3H-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol, Basic fibroblast growth factor receptor 1
著者Bae, J.H, Lew, E.D, Yuzawa, S, Tome, F, Lax, I, Schlessinger, J.
登録日2009-03-24
公開日2009-08-18
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Cell(Cambridge,Mass.), 138, 2009
3GQI
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BU of 3gqi by Molmil
Crystal Structure of activated receptor tyrosine kinase in complex with substrates
分子名称: Basic fibroblast growth factor receptor 1, DECAVANADATE, MAGNESIUM ION, ...
著者Bae, J.H, Lew, E.D, Yuzawa, S, Tome, F, Lax, I, Schlessinger, J.
登録日2009-03-24
公開日2009-08-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Cell(Cambridge,Mass.), 138, 2009
2AXM
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BU of 2axm by Molmil
HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR
分子名称: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, ACIDIC FIBROBLAST GROWTH FACTOR
著者Digabriele, A.D, Lax, I, Chen, D.I, Svahn, C.M, Jaye, M, Schlessinger, J, Hendrickson, W.A.
登録日1997-10-20
公開日1998-04-22
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of a heparin-linked biologically active dimer of fibroblast growth factor.
Nature, 393, 1998
2E9W
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BU of 2e9w by Molmil
Crystal structure of the extracellular domain of Kit in complex with stem cell factor (SCF)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Kit ligand, Mast/stem cell growth factor receptor
著者Yuzawa, S, Opatowsky, Y, Zhang, Z, Mandiyan, V, Lax, I, Schlessinger, J.
登録日2007-01-27
公開日2007-08-07
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor
Cell(Cambridge,Mass.), 130, 2007
2EC8
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BU of 2ec8 by Molmil
Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Mast/stem cell growth factor receptor
著者Yuzawa, S, Opatowsky, Y, Zhang, Z, Mandiyan, V, Lax, I, Schlessinger, J.
登録日2007-02-11
公開日2007-08-07
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor
Cell(Cambridge,Mass.), 130, 2007
6NFJ
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BU of 6nfj by Molmil
Structure of Beta-Klotho in Complex with FGF19 C-terminal peptide
分子名称: Beta-klotho, Fibroblast growth factor 19, Nanobody 30
著者Kuzina, E, Schlessinger, J, Lee, S.
登録日2018-12-20
公開日2019-04-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Structures of ligand-occupied beta-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
8DFM
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BU of 8dfm by Molmil
Ectodomain of full-length wild-type KIT-SCF dimers
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ...
著者Krimmer, S.G, Bertoletti, N, Mi, W, Schlessinger, J.
登録日2022-06-22
公開日2023-03-29
最終更新日2023-04-05
実験手法ELECTRON MICROSCOPY (3.45 Å)
主引用文献Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DFQ
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BU of 8dfq by Molmil
Ectodomain of full-length KIT(T417I,delta418-419)-SCF dimers
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ...
著者Krimmer, S.G, Bertoletti, N, Mi, W, Schlessinger, J.
登録日2022-06-22
公開日2023-03-29
最終更新日2023-04-05
実験手法ELECTRON MICROSCOPY (3.96 Å)
主引用文献Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Proc.Natl.Acad.Sci.USA, 120, 2023
8DFP
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BU of 8dfp by Molmil
Ectodomain of full-length KIT(DupA502,Y503)-SCF dimers
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Mast/stem cell growth factor receptor Kit, ...
著者Bertoletti, N, Krimmer, S.G, Mi, W, Schlessinger, J.
登録日2022-06-22
公開日2023-03-29
最終更新日2023-04-05
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Proc.Natl.Acad.Sci.USA, 120, 2023
5VAN
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BU of 5van by Molmil
Crystal Structure of Beta-Klotho
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Lee, S, Schlessinger, J.
登録日2017-03-27
公開日2018-01-31
最終更新日2021-03-24
実験手法X-RAY DIFFRACTION (2.202 Å)
主引用文献Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Nature, 553, 2018
5VAK
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BU of 5vak by Molmil
Crystal Structure of Beta-Klotho, Domain 1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-klotho, ...
著者Lee, S, Schlessinger, J.
登録日2017-03-27
公開日2018-01-31
最終更新日2021-03-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Nature, 553, 2018
5VAQ
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Crystal Structure of Beta-Klotho in Complex with FGF21CT
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-klotho, Fibroblast growth factor 21, ...
著者Lee, S, Schlessinger, J.
登録日2017-03-27
公開日2018-01-31
最終更新日2021-03-24
実験手法X-RAY DIFFRACTION (2.606 Å)
主引用文献Structures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Nature, 553, 2018
2ERM
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BU of 2erm by Molmil
Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue
分子名称: 2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, Heparin-binding growth factor 1, ISOPROPYL ALCOHOL
著者Canales, A, Lozano, R, Nieto, P.M, Martin-Lomas, M, Gimenez-Gallego, G, Jimenez-Barbero, J.
登録日2005-10-25
公開日2006-10-03
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue.
Febs J., 273, 2006
1QQL
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BU of 1qql by Molmil
THE CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 7/1 CHIMERA
分子名称: FIBROBLAST GROWTH FACTOR 7/1 CHIMERA
著者Ye, S, Luo, Y, Pelletier, H, McKeehan, W.L.
登録日1999-06-07
公開日2000-01-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs.
Biochemistry, 40, 2001
1QQK
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THE CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 7 (KERATINOCYTE GROWTH FACTOR)
分子名称: FIBROBLAST GROWTH FACTOR 7
著者Ye, S, Luo, Y, Pelletier, H, McKeehan, W.L.
登録日1999-06-07
公開日2000-01-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs.
Biochemistry, 40, 2001
7LIR
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BU of 7lir by Molmil
Structure of the invertebrate ALK GRD
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ALK tyrosine kinase receptor homolog scd-2, ...
著者Stayrook, S, Li, T, Klein, D.E.
登録日2021-01-27
公開日2021-11-24
最終更新日2021-12-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for ligand reception by anaplastic lymphoma kinase.
Nature, 600, 2021
7LS0
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BU of 7ls0 by Molmil
Structure of the Human ALK GRD bound to AUG
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ALK tyrosine kinase receptor fused with ALK and LTK ligand 2, CITRIC ACID
著者Stayrook, S, Li, T, Klein, D.E.
登録日2021-02-17
公開日2021-11-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Structural basis for ligand reception by anaplastic lymphoma kinase.
Nature, 600, 2021
7LRZ
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Structure of the Human ALK GRD
分子名称: ALK tyrosine kinase receptor
著者Stayrook, S, Li, T, Klein, D.E.
登録日2021-02-17
公開日2021-11-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Structural basis for ligand reception by anaplastic lymphoma kinase.
Nature, 600, 2021
7N00
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BU of 7n00 by Molmil
Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025 in complex with AUG-alpha
分子名称: ALK and LTK ligand 2, ALK tyrosine kinase receptor
著者Reshetnyak, A.V, Myasnikov, A.G, Rossi, P, Miller, D.J, Kalodimos, C.G.
登録日2021-05-24
公開日2021-11-24
最終更新日2021-12-15
実験手法ELECTRON MICROSCOPY (2.27 Å)
主引用文献Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Nature, 600, 2021

 

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