Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit

Summary for 2EC8

Related2E9W 1EXZ
DescriptorMast/stem cell growth factor receptor, N-ACETYL-D-GLUCOSAMINE (2 entities in total)
Functional Keywordsglycoprotein, receptor tyrosine kinase, growth factor cytokine, dimerization, transferase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P10721
Total number of polymer chains1
Total molecular weight60160.47
Yuzawa, S.,Opatowsky, Y.,Zhang, Z.,Mandiyan, V.,Lax, I.,Schlessinger, J. (deposition date: 2007-02-11, release date: 2007-08-07, Last modification date: 2011-07-13)
Primary citation
Yuzawa, S.,Opatowsky, Y.,Zhang, Z.,Mandiyan, V.,Lax, I.,Schlessinger, J.
Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor
Cell(Cambridge,Mass.), 130:323-334, 2007
PubMed: 17662946 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2007.05.055
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.276283.3%15.3%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution