2E9W

Crystal structure of the extracellular domain of Kit in complex with stem cell factor (SCF)

Summary for 2E9W

Related1EXZ 2EC8
DescriptorMast/stem cell growth factor receptor, Kit ligand, N-ACETYL-D-GLUCOSAMINE (3 entities in total)
Functional Keywordsglycoprotein, receptor tyrosine kinase, growth factor cytokine, dimerization, transferase-hormone complex, transferase/hormone
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein P10721
Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein (By similarity). Soluble KIT ligand: Secreted P21583
Total number of polymer chains4
Total molecular weight143235.13
Authors
Yuzawa, S.,Opatowsky, Y.,Zhang, Z.,Mandiyan, V.,Lax, I.,Schlessinger, J. (deposition date: 2007-01-27, release date: 2007-08-07, Last modification date: 2011-07-13)
Primary citation
Yuzawa, S.,Opatowsky, Y.,Zhang, Z.,Mandiyan, V.,Lax, I.,Schlessinger, J.
Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor
Cell(Cambridge,Mass.), 130:323-334, 2007
PubMed: 17662946 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2007.05.055
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.264495.1%11.0%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution