2E9W

Crystal structure of the extracellular domain of Kit in complex with stem cell factor (SCF)

Summary for 2E9W

• Entry DOI: 10.2210/pdb2e9w/pdb
• Related: 1EXZ 2EC8
• Descriptor: Mast/stem cell growth factor receptor, Kit ligand, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: glycoprotein, receptor tyrosine kinase, growth factor cytokine, dimerization, transferase-hormone complex, transferase/hormone
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 143235.13

Authors

Yuzawa, S.,Opatowsky, Y.,Zhang, Z.,Mandiyan, V.,Lax, I.,Schlessinger, J. (deposition date: 2007-01-27, release date: 2007-08-07, Last modification date: 2023-10-25)

• Primary citation: Yuzawa, S.,Opatowsky, Y.,Zhang, Z.,Mandiyan, V.,Lax, I.,Schlessinger, J.; Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor; Cell(Cambridge,Mass.), 130:323-334, 2007; PubMed: 17662946; DOI: 10.1016/j.cell.2007.05.055

Experimental method

X-RAY DIFFRACTION (3.5 Å)