2E9W
Crystal structure of the extracellular domain of Kit in complex with stem cell factor (SCF)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Mast/stem cell growth factor receptor | polymer | 489 | 54946.6 | 2 | UniProt (P10721) Pfam (PF00047) In PDB | Homo sapiens (human) | SCFR, Proto-oncogene tyrosine-protein kinase Kit, c-kit, CD117 antigen |
| 2 | C, D | Kit ligand | polymer | 141 | 16007.3 | 2 | UniProt (P21583) Pfam (PF02404) In PDB | Homo sapiens (human) | C-kit ligand, Stem cell factor, SCF, Mast cell growth factor, MGF |
| 3 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
A, B: 26 - 514 (UniProt: P10721)
| PDB | External Database | Details |
|---|---|---|
| Ser 130 | Asn 130 | engineered mutation |
| Ser 145 | Asn 145 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 141907.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1327.2 | |
| All* | Total formula weight | 143235.1 |
