7LS0

Structure of the Human ALK GRD bound to AUG

Summary for 7LS0

• Entry DOI: 10.2210/pdb7ls0/pdb
• Descriptor: ALK tyrosine kinase receptor fused with ALK and LTK ligand 2, CITRIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: glycine rich domain, neuroblastoma, cancer, oncogene, signaling protein, transferase, transferase-transferase activator complex, transferase/transferase activator
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 190104.30

Authors

Stayrook, S.,Li, T.,Klein, D.E. (deposition date: 2021-02-17, release date: 2021-11-24, Last modification date: 2023-10-18)

• Primary citation: Li, T.,Stayrook, S.E.,Tsutsui, Y.,Zhang, J.,Wang, Y.,Li, H.,Proffitt, A.,Krimmer, S.G.,Ahmed, M.,Belliveau, O.,Walker, I.X.,Mudumbi, K.C.,Suzuki, Y.,Lax, I.,Alvarado, D.,Lemmon, M.A.,Schlessinger, J.,Klein, D.E.; Structural basis for ligand reception by anaplastic lymphoma kinase.; Nature, 600:148-152, 2021; PubMed: 34819665; DOI: 10.1038/s41586-021-04141-7

Experimental method

X-RAY DIFFRACTION (3.05 Å)