7LS0

Structure of the Human ALK GRD bound to AUG

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	ALK tyrosine kinase receptor fused with ALK and LTK ligand 2	polymer	451	47374.7	4	UniProt (Q9UM73) UniProt (Q6UX46) Pfam (PF12810) Pfam (PF15129)	Homo sapiens (Human)	Anaplastic lymphoma kinase,Augmentor alpha,AUG-alpha,Protein FAM150B
2	E, F (A)	CITRIC ACID	non-polymer		192.1	2	Chemie (CIT)
3	G (D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A, B, C, D: 678 - 1030 (UniProt: Q9UM73)

PDB	External Database	Details
Gly 663	-	expression tag
His 664	-	expression tag
His 665	-	expression tag
His 666	-	expression tag
His 667	-	expression tag
His 668	-	expression tag
His 669	-	expression tag
His 670	-	expression tag
His 671	-	expression tag
Ile 672	-	expression tag
Glu 673	-	expression tag
Gly 674	-	expression tag
Arg 675	-	expression tag
Ser 676	-	expression tag
Leu 677	-	expression tag
Gly 1031	-	linker
Gly 1032	-	linker
Ser 1033	-	linker
Gly 1034	-	linker
Gly 1035	-	linker
Ser 1036	-	linker
Gly 1037	-	linker
Gly 1038	-	linker
Ser 1039	-	linker
Gly 1040	-	linker
Gly 1041	-	linker
Ser 1042	-	linker
Gly 1043	-	linker
Gly 1044	-	linker
Ala 1045	-	linker

A, B, C, D: 1046 - 1113 (UniProt: Q6UX46)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	189498.8
Non-Polymers*	Number of molecules	3
	Total formula weight	605.5
All*	Total formula weight	190104.3

*Water molecules are not included.