3GQI

Crystal Structure of activated receptor tyrosine kinase in complex with substrates

Summary for 3GQI

• Entry DOI: 10.2210/pdb3gqi/pdb
• Related: 3GQL
• Descriptor: Basic fibroblast growth factor receptor 1, Phospholipase C-gamma-1, DECAVANADATE, ... (6 entities in total)
• Functional Keywords: phosphorylated kinase, py-recognition, tandem sh2 domains, atp analog, atp-binding, craniosynostosis, disease mutation, disulfide bond, dwarfism, glycoprotein, heparin-binding, hypogonadotropic hypogonadism, immunoglobulin domain, kallmann syndrome, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, transferase, transmembrane, tyrosine-protein kinase, hydrolase, lipid degradation, sh2 domain, sh3 domain, transducer, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P11362; Cell projection, lamellipodium : P10686
• Total number of polymer chains: 2
• Total formula weight: 65292.33

Authors

Bae, J.H.,Lew, E.D.,Yuzawa, S.,Tome, F.,Lax, I.,Schlessinger, J. (deposition date: 2009-03-24, release date: 2009-08-18, Last modification date: 2023-11-22)

• Primary citation: Bae, J.H.,Lew, E.D.,Yuzawa, S.,Tome, F.,Lax, I.,Schlessinger, J.; The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.; Cell(Cambridge,Mass.), 138:514-524, 2009; PubMed: 19665973; DOI: 10.1016/j.cell.2009.05.028

Experimental method

X-RAY DIFFRACTION (2.5 Å)