3GQI

Crystal Structure of activated receptor tyrosine kinase in complex with substrates

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Basic fibroblast growth factor receptor 1	polymer	326	37482.7	1	UniProt (P11362) Pfam (PF07714) In PDB	Homo sapiens (human)	FGFR-1, bFGF-R, Fms-like tyrosine kinase 2, c-fgr
2	B	Phospholipase C-gamma-1	polymer	226	26322.7	1	UniProt (P10686) Pfam (PF00017) In PDB	Rattus norvegicus (rat)	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1, Phosphoinositide phospholipase C, PLC-gamma-1, PLC-II, PLC-148
3	A	DECAVANADATE	non-polymer		957.4	1	Chemie (DVT)
4	A	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP)
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6		water	water		18.0	77	Chemie (HOH)

Sequence modifications

A: 458 - 774 (UniProt: P11362)

PDB	External Database	Details
Met 449	-	expression tag
Gly 450	-	expression tag
His 451	-	expression tag
His 452	-	expression tag
His 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
Met 457	-	expression tag
Ala 488	Cys 488	engineered mutation
Phe 583	Tyr 583	engineered mutation
Ser 584	Cys 584	engineered mutation
Phe 585	Tyr 585	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	63805.4
Non-Polymers*	Number of molecules	3
	Total formula weight	1486.9
All*	Total formula weight	65292.3

*Water molecules are not included.