1AXM

HEPARIN-LINKED BIOLOGICALLY-ACTIVE DIMER OF FIBROBLAST GROWTH FACTOR

Summary for 1AXM

• Entry DOI: 10.2210/pdb1axm/pdb
• Descriptor: ACIDIC FIBROBLAST GROWTH FACTOR, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ... (4 entities in total)
• Functional Keywords: human acidic fibroblast growth factor, heparin decasaccharide, growth factor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 96434.20

Authors

DiGabriele, A.D.,Lax, I.,Chen, D.I.,Svahn, C.M.,Jaye, M.,Schlessinger, J.,Hendrickson, W.A. (deposition date: 1997-10-16, release date: 1998-04-22, Last modification date: 2023-08-02)

• Primary citation: DiGabriele, A.D.,Lax, I.,Chen, D.I.,Svahn, C.M.,Jaye, M.,Schlessinger, J.,Hendrickson, W.A.; Structure of a heparin-linked biologically active dimer of fibroblast growth factor.; Nature, 393:812-817, 1998; PubMed: 9655399; DOI: 10.1038/31741

Experimental method

X-RAY DIFFRACTION (3 Å)