7N00

Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025 in complex with AUG-alpha

Summary for 7N00

Entry DOI	10.2210/pdb7n00/pdb
Related	7MZW 7MZX 7MZY 7MZZ
EMDB information	24095
Descriptor	ALK tyrosine kinase receptor, ALK and LTK ligand 2 (2 entities in total)
Functional Keywords	anaplastic lymphoma kinase, receptor tyrosine kinases, rtk, fam150, de novo protein, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	108035.14
Authors	Reshetnyak, A.V.,Myasnikov, A.G.,Rossi, P.,Miller, D.J.,Kalodimos, C.G. (deposition date: 2021-05-24, release date: 2021-11-24, Last modification date: 2021-12-15)
Primary citation	Reshetnyak, A.V.,Rossi, P.,Myasnikov, A.G.,Sowaileh, M.,Mohanty, J.,Nourse, A.,Miller, D.J.,Lax, I.,Schlessinger, J.,Kalodimos, C.G. Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature, 600:153-157, 2021 Cited by PubMed: 34819673 DOI: 10.1038/s41586-021-04140-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.27 Å)

Structure validation