7N00
Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025 in complex with AUG-alpha
Summary for 7N00
Entry DOI | 10.2210/pdb7n00/pdb |
Related | 7MZW 7MZX 7MZY 7MZZ |
EMDB information | 24095 |
Descriptor | ALK tyrosine kinase receptor, ALK and LTK ligand 2 (2 entities in total) |
Functional Keywords | anaplastic lymphoma kinase, receptor tyrosine kinases, rtk, fam150, de novo protein, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 108035.14 |
Authors | Reshetnyak, A.V.,Myasnikov, A.G.,Rossi, P.,Miller, D.J.,Kalodimos, C.G. (deposition date: 2021-05-24, release date: 2021-11-24, Last modification date: 2021-12-15) |
Primary citation | Reshetnyak, A.V.,Rossi, P.,Myasnikov, A.G.,Sowaileh, M.,Mohanty, J.,Nourse, A.,Miller, D.J.,Lax, I.,Schlessinger, J.,Kalodimos, C.G. Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature, 600:153-157, 2021 Cited by PubMed: 34819673DOI: 10.1038/s41586-021-04140-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.27 Å) |
Structure validation
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