7N00

Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025 in complex with AUG-alpha

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, C)	ALK tyrosine kinase receptor	polymer	379	39377.6	2	UniProt (Q9UM73) Pfam (PF12810)	Homo sapiens (Human)	Anaplastic lymphoma kinase
2	C, D (B, D)	ALK and LTK ligand 2	polymer	128	14640.0	2	UniProt (Q6UX46) Pfam (PF15129)	Homo sapiens (Human)	Augmentor alpha,AUG-alpha,Protein FAM150B

Sequence modifications

A, C: 648 - 1025 (UniProt: Q9UM73)

PDB	External Database	Details
Gly 647	-	expression tag

B, D: 25 - 152 (UniProt: Q6UX46)

PDB	External Database	Details
Tyr 66	Cys 66	engineered mutation

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.