Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation

Summary for 4PGZ

DescriptorMast/stem cell growth factor receptor Kit, N-ACETYL-D-GLUCOSAMINE, COBALT (II) ION, ... (4 entities in total)
Functional Keywordsreceptor tyrosine kinase, kit receptor, igsf, cancer, surface receptor, transferase
Biological sourceHomo sapiens (Human)
Cellular locationIsoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cytoplasm P10721
Total number of polymer chains3
Total molecular weight71050.96
Reshetnyak, A.V.,Boggon, T.J.,Lax, I.,Schlessinger, J. (deposition date: 2014-05-03, release date: 2015-03-18)
Primary citation
Reshetnyak, A.V.,Opatowsky, Y.,Boggon, T.J.,Folta-Stogniew, E.,Tome, F.,Lax, I.,Schlessinger, J.
The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.
Mol.Cell, 57:191-201, 2015
PubMed: 25544564 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2014.11.021
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.262401.2%8.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution