4PGZ
Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (C, A, B) | Mast/stem cell growth factor receptor Kit | polymer | 208 | 23364.2 | 3 | UniProt (P10721) | Homo sapiens (Human) | SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| 2 | D, G, K (C, A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 3 | E, F, H, I, J (C, A) | COBALT (II) ION | non-polymer | 58.9 | 5 | Chemie (CO) | |||
| 4 | L, M, N (C, A, B) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
C, A, B: 308 - 514 (UniProt: P10721)
| PDB | External Database | Details |
|---|---|---|
| Gly 305 | - | expression tag |
| Ala 306 | - | expression tag |
| Met 307 | - | expression tag |
| - | Thr 417 | deletion |
| - | Tyr 418 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 70092.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 958.3 | |
| All* | Total formula weight | 71051.0 |
