4PGZ
Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | C, A, B | Mast/stem cell growth factor receptor Kit | polymer | 208 | 23364.2 | 3 | UniProt (P10721) In PDB | Homo sapiens (Human) | SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
2 | C, A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
3 | C, A | COBALT (II) ION | non-polymer | 58.9 | 5 | Chemie (CO) | |||
4 | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
C, A, B: 308 - 514 (UniProt: P10721)
PDB | External Database | Details |
---|---|---|
Gly 305 | - | expression tag |
Ala 306 | - | expression tag |
Met 307 | - | expression tag |
- | Thr 417 | deletion |
- | Tyr 418 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 70092.7 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 958.3 | |
All* | Total formula weight | 71051.0 |