2ERM

Solution structure of a biologically active human FGF-1 monomer, complexed to a hexasaccharide heparin-analogue

Summary for 2ERM

DescriptorHeparin-binding growth factor 1, 2-O-sulfo-alpha-L-idopyranuronic acid, N-SULFO-ALPHA-D-GLUCOSAMINE, ... (6 entities in total)
Functional Keywordsheparin-like hexasaccharide, fibroblast growth factor, protein-carbohydrate complex, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationSecreted P05230
Total number of polymer chains1
Total molecular weight47016.47
Authors
Canales, A.,Lozano, R.,Nieto, P.M.,Martin-Lomas, M.,Gimenez-Gallego, G.,Jimenez-Barbero, J. (deposition date: 2005-10-25, release date: 2006-10-03, Last modification date: 2011-07-13)
Primary citation
Canales, A.,Lozano, R.,Lopez-Mendez, B.,Angulo, J.,Ojeda, R.,Nieto, P.M.,Martin-Lomas, M.,Gimenez-Gallego, G.,Jimenez-Barbero, J.
Solution NMR structure of a human FGF-1 monomer, activated by a hexasaccharide heparin-analogue.
Febs J., 273:4716-4727, 2006
PubMed: 16995857 (PDB entries with the same primary citation)
DOI: 10.1111/j.1742-4658.2006.05474.x
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers14.5%11.4%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

Molmil generated image of 2erm
no rotation
Molmil generated image of 2erm
rotated about x axis by 90°
Molmil generated image of 2erm
rotated about y axis by 90°