6NFJ

Structure of Beta-Klotho in Complex with FGF19 C-terminal peptide

Summary for 6NFJ

Entry DOI	10.2210/pdb6nfj/pdb
Descriptor	Beta-klotho, Nanobody 30, Fibroblast growth factor 19 (3 entities in total)
Functional Keywords	klotho, fgf19, nanobody, receptor tyrosine kinase, signaling, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	261285.48
Authors	Kuzina, E.,Schlessinger, J.,Lee, S. (deposition date: 2018-12-20, release date: 2019-04-03, Last modification date: 2023-10-11)
Primary citation	Kuzina, E.S.,Ung, P.M.,Mohanty, J.,Tome, F.,Choi, J.,Pardon, E.,Steyaert, J.,Lax, I.,Schlessinger, A.,Schlessinger, J.,Lee, S. Structures of ligand-occupied beta-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity. Proc. Natl. Acad. Sci. U.S.A., 116:7819-7824, 2019 Cited by PubMed: 30944224 DOI: 10.1073/pnas.1822055116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.19 Å)

Structure validation