4K94

Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19

Summary for 4K94

• Entry DOI: 10.2210/pdb4k94/pdb
• Related: 4K9E
• Descriptor: Fab19 heavy chain, Fab19 light chain, Mast/stem cell growth factor receptor Kit, ... (5 entities in total)
• Functional Keywords: receptor tyrosine kinase (rtk), fab, ig sf, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 72265.44

Authors

Resheynyak, A.V.,Boggon, T.J.,Lax, I.,Schlessinger, J. (deposition date: 2013-04-19, release date: 2013-10-16, Last modification date: 2020-07-29)

• Primary citation: Reshetnyak, A.V.,Nelson, B.,Shi, X.,Boggon, T.J.,Pavlenco, A.,Mandel-Bausch, E.M.,Tome, F.,Suzuki, Y.,Sidhu, S.S.,Lax, I.,Schlessinger, J.; Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.; Proc.Natl.Acad.Sci.USA, 110:17832-17837, 2013; PubMed: 24127596; DOI: 10.1073/pnas.1317118110

Experimental method

X-RAY DIFFRACTION (2.4 Å)