8RVE
 
 | | Vimentin intermediate filament | | 分子名称: | Vimentin | | 著者 | Eibauer, M, Medalia, O. | | 登録日 | 2024-02-01 | | 公開日 | 2024-04-10 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | | 主引用文献 | Vimentin filaments integrate low-complexity domains in a complex helical structure.
Nat.Struct.Mol.Biol., 31, 2024
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7ZXV
 | | Orange Carotenoid Protein Trp-288 BTA mutant | | 分子名称: | CHLORIDE ION, Orange carotenoid-binding protein, beta,beta-caroten-4-one, ... | | 著者 | Moldenhauer, M, Tseng, H.-W, Kraskov, A, Tavraz, N.N, Hildebrandt, P, Hochberg, G, Essen, L.-O, Budisa, N, Korf, L, Maksimov, E.G, Friedrich, T. | | 登録日 | 2022-05-23 | | 公開日 | 2023-02-01 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Parameterization of a single H-bond in Orange Carotenoid Protein by atomic mutation reveals principles of evolutionary design of complex chemical photosystems.
Front Mol Biosci, 10, 2023
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4GH7
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1A8G
 | | HIV-1 PROTEASE IN COMPLEX WITH SDZ283-910 | | 分子名称: | HIV-1 PROTEASE, benzyl [(1R)-1-({(1S,2S,3S)-1-benzyl-2-hydroxy-4-({(1S)-1-[(2-hydroxy-4-methoxybenzyl)carbamoyl]-2-methylpropyl}amino)-3-[(4-methoxybenzyl)amino]-4-oxobutyl}carbamoyl)-2,2-dimethylpropyl]carbamate | | 著者 | Kallen, J, Billich, A, Scholz, D, Auer, M, Kungl, A. | | 登録日 | 1998-03-24 | | 公開日 | 1998-07-15 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulations.
J.Mol.Biol., 286, 1999
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1ROD
 | | CHIMERIC PROTEIN OF INTERLEUKIN 8 AND HUMAN MELANOMA GROWTH STIMULATING ACTIVITY PROTEIN, NMR | | 分子名称: | CHIMERIC PROTEIN OF INTERLEUKIN 8 AND HUMAN MELANOMA GROWTH STIMULATING ACTIVITY PROTEIN | | 著者 | Roesch, P, Sticht, H, Auer, M, Schmitt, B, Besemer, J, Horcher, M, Kirsch, T, Lindley, I.J.D. | | 登録日 | 1995-11-24 | | 公開日 | 1996-06-10 | | 最終更新日 | 2022-03-02 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and activity of a chimeric interleukin-8-melanoma-growth-stimulatory-activity protein.
Eur.J.Biochem., 235, 1996
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1QLB
 | | respiratory complex II-like fumarate reductase from Wolinella succinogenes | | 分子名称: | CALCIUM ION, DODECYL-BETA-D-MALTOSIDE, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Lancaster, C.R.D, Kroeger, A, Auer, M, Michel, H. | | 登録日 | 1999-08-25 | | 公開日 | 1999-11-29 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Structure of Fumarate Reductase from Wolinella Succinogenes at 2.2 Angstroms Resolution
Nature, 402, 1999
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1PW4
 | | Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli | | 分子名称: | Glycerol-3-phosphate transporter | | 著者 | Huang, Y, Lemieux, M.J, Song, J, Auer, M, Wang, D.N. | | 登録日 | 2003-06-30 | | 公開日 | 2003-08-05 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure and Mechanism of the Glycerol-3-Phosphate Transporter from Escherichia Coli
Science, 301, 2003
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6ZLE
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7NM5
 | | Solution structure of MLKL executioner domain in complex with a fragment | | 分子名称: | 2-[(~{S})-methoxy-(4-phenylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | 登録日 | 2021-02-23 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J.Med.Chem., 64, 2021
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7NM2
 | | Solution structure of MLKL executioner domain in complex with a fragment | | 分子名称: | 2-[(~{S})-methoxy-(4-propan-2-ylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | 登録日 | 2021-02-23 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J.Med.Chem., 64, 2021
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7NM4
 | | Solution structure of MLKL executioner domain in complex with a fragment | | 分子名称: | (~{S})-1~{H}-benzimidazol-2-yl-(4-propan-2-ylphenyl)methanol, Mixed lineage kinase domain-like protein | | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | 登録日 | 2021-02-23 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J.Med.Chem., 64, 2021
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2MBK
 | | The Clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed | | 分子名称: | Crossveinless 2 | | 著者 | Mueller, T.D, Fiebig, J.E, Weidauer, S.E, Qiu, L, Bauer, M, Schmieder, P, Beerbaum, M, Zhang, J, Oschkinat, H, Sebald, W. | | 登録日 | 2013-08-02 | | 公開日 | 2013-10-16 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Clip-Segment of the von Willebrand Domain 1 of the BMP Modulator Protein Crossveinless 2 Is Preformed.
Molecules, 18, 2013
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6ZPR
 | | Solution structure of MLKL executioner domain in complex with a covalent inhibitor | | 分子名称: | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione, Mixed lineage kinase domain-like protein,Mixed lineage kinase domain-like protein | | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | 登録日 | 2020-07-09 | | 公開日 | 2020-12-16 | | 最終更新日 | 2021-01-06 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6ZVO
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6ZZ1
 | | Crystal structure of MLKL executioner domain in complex with a covalent inhibitor | | 分子名称: | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione, Mixed lineage kinase domain-like protein | | 著者 | Fiegen, D, Bauer, M, Nar, H. | | 登録日 | 2020-08-03 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6EQC
 | | Cryo-EM reconstruction of a complex of a binding protein and human adenovirus C5 hexon | | 分子名称: | Hexon protein, scFv of 9C12 antibody | | 著者 | Schmid, M, Ernst, P, Honegger, A, Suomalainen, M, Zimmermann, M, Braun, L, Stauffer, S, Thom, C, Dreier, B, Eibauer, M, Kipar, A, Vogel, V, Greber, U.F, Medalia, O, Plueckthun, A. | | 登録日 | 2017-10-12 | | 公開日 | 2018-02-07 | | 最終更新日 | 2018-02-14 | | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | | 主引用文献 | Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control.
Nat Commun, 9, 2018
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4CMP
 | | Crystal structure of S. pyogenes Cas9 | | 分子名称: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, SULFATE ION | | 著者 | Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A. | | 登録日 | 2014-01-16 | | 公開日 | 2014-02-12 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation.
Science, 343, 2014
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4CMQ
 | | Crystal structure of Mn-bound S.pyogenes Cas9 | | 分子名称: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MANGANESE (II) ION, SULFATE ION | | 著者 | Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A. | | 登録日 | 2014-01-17 | | 公開日 | 2014-02-12 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | | 主引用文献 | Structures of Cas9 Endonucleases Reveal RNA- Mediated Conformational Activation
Science, 343, 2014
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4AEL
 | | PDE10A in complex with the inhibitor AZ5 | | 分子名称: | 2-(2'-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE, CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, ... | | 著者 | Bauer, U, Giordanetto, F, Bauer, M, OMahony, G, Johansson, K.E, Knecht, W, Hartleib-Geschwindner, J, Toppner Carlsson, E, Enroth, C, Sjogren, T. | | 登録日 | 2012-01-11 | | 公開日 | 2012-01-25 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery of 4-Hydroxy-1,6-Naphthyridine-3-Carbonitrile Derivatives as Novel Pde10A Inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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2YKL
 | | Structure of human anti-nicotine Fab fragment in complex with nicotine-11-yl-methyl-(4-ethylamino-4-oxo)-butanoate | | 分子名称: | FAB FRAGMENT, HEAVY CHAIN, LIGHT CHAIN, ... | | 著者 | Tars, K, Kotelovica, S, Lipowsky, G, Bauer, M, Beerli, R, Bachmann, M, Maurer, P. | | 登録日 | 2011-05-27 | | 公開日 | 2011-11-16 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Different Binding Modes of Free and Carrier-Protein-Coupled Nicotine in a Human Monoclonal Antibody.
J.Mol.Biol., 415, 2012
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2YK1
 | | Structure of human anti-nicotine Fab fragment in complex with nicotine | | 分子名称: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, FAB FRAGMENT, HEAVY CHAIN, ... | | 著者 | Tars, K, Kotelovica, S, Lipowsky, G, Bauer, M, Beerli, R, Bachmann, M, Maurer, P. | | 登録日 | 2011-05-25 | | 公開日 | 2011-11-16 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Different Binding Modes of Free and Carrier-Protein-Coupled Nicotine in a Human Monoclonal Antibody.
J.Mol.Biol., 415, 2012
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1PFX
 | | PORCINE FACTOR IXA | | 分子名称: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, FACTOR IXA | | 著者 | Brandstetter, H, Bauer, M, Huber, R, Lollar, P, Bode, W. | | 登録日 | 1995-07-19 | | 公開日 | 1996-08-17 | | 最終更新日 | 2013-02-27 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B.
Proc.Natl.Acad.Sci.USA, 92, 1995
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1SMP
 | | CRYSTAL STRUCTURE OF A COMPLEX BETWEEN SERRATIA MARCESCENS METALLO-PROTEASE AND AN INHIBITOR FROM ERWINIA CHRYSANTHEMI | | 分子名称: | CALCIUM ION, ERWINIA CHRYSANTHEMI INHIBITOR, SERRATIA METALLO PROTEINASE, ... | | 著者 | Baumann, U, Bauer, M, Letoffe, S, Delepelaire, P, Wandersman, C. | | 登録日 | 1995-01-13 | | 公開日 | 1996-04-03 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of a complex between Serratia marcescens metallo-protease and an inhibitor from Erwinia chrysanthemi.
J.Mol.Biol., 248, 1995
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1DB2
 | | CRYSTAL STRUCTURE OF NATIVE PLASMINOGEN ACTIVATOR INHIBITOR-1 | | 分子名称: | PLASMINOGEN ACTIVATOR INHIBITOR-1 | | 著者 | Nar, H, Bauer, M, Stassen, J.M, Lang, D, Gils, A, Declerck, P. | | 登録日 | 1999-11-02 | | 公開日 | 1999-11-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation.
J.Mol.Biol., 297, 2000
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2X7O
 | | Crystal structure of TGFbRI complexed with an indolinone inhibitor | | 分子名称: | (3Z)-N-ETHYL-N-METHYL-2-OXO-3-(PHENYL{[4-(PIPERIDIN-1-YLMETHYL)PHENYL]AMINO}METHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-6-CARBOXAMIDE, TGF-BETA RECEPTOR TYPE I | | 著者 | Roth, G.J, Heckel, A, Brandl, T, Grauert, M, Hoerer, S, Kley, J.T, Schnapp, G, Baum, P, Mennerich, D, Schnapp, A, Park, J.E. | | 登録日 | 2010-03-03 | | 公開日 | 2010-10-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Design, Synthesis and Evaluation of Indolinones as Inhibitors of the Transforming Growth Factor Beta Receptor I (Tgfbri)
J.Med.Chem., 53, 2010
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