4AEL

PDE10A in complex with the inhibitor AZ5

Summary for 4AEL

Entry DOI	10.2210/pdb4ael/pdb
Related	1LRB 2WEY 2Y0J 2Y5U 2Y5V 2Y5X
Descriptor	CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase, hit-to-lead, enzyme inhibitor, naphtyridine
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm: Q9Y233
Total number of polymer chains	2
Total formula weight	79844.66
Authors	Bauer, U.,Giordanetto, F.,Bauer, M.,OMahony, G.,Johansson, K.E.,Knecht, W.,Hartleib-Geschwindner, J.,Toppner Carlsson, E.,Enroth, C.,Sjogren, T. (deposition date: 2012-01-11, release date: 2012-01-25, Last modification date: 2023-12-20)
Primary citation	Bauer, U.,Giordanetto, F.,Bauer, M.,O'Mahony, G.,Johansson, K.E.,Knecht, W.,Hartleib-Geschwindner, J.,Carlsson, E.T.,Enroth, C. Discovery of 4-Hydroxy-1,6-Naphthyridine-3-Carbonitrile Derivatives as Novel Pde10A Inhibitors. Bioorg.Med.Chem.Lett., 22:1944-, 2012 Cited by PubMed: 22321214 DOI: 10.1016/J.BMCL.2012.01.046 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation