4AEL
PDE10A in complex with the inhibitor AZ5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A | polymer | 344 | 39465.2 | 2 | UniProt (Q9Y233) | HOMO SAPIENS (HUMAN) | |
| 2 | C, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, H (A, B) | 2-(2'-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE | non-polymer | 367.4 | 2 | Chemie (4HN) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 313 | Chemie (HOH) |
Sequence modifications
A, B: 448 - 789 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| Ser 446 | - | expression tag |
| Asn 447 | - | expression tag |
| Ala 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 78930.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 914.2 | |
| All* | Total formula weight | 79844.7 |
