4GH7

Crystal structure of Anticalin N7A in complex with oncofetal fibronectin fragment Fn7B8

Summary for 4GH7

Entry DOI	10.2210/pdb4gh7/pdb
Descriptor	Neutrophil gelatinase-associated lipocalin, Fibronectin (3 entities in total)
Functional Keywords	lipocalin, anticalin, human fibronectin, fn type iii domain, oncofetal fibronectin splice variant p02751-7, lipocalin-based binding protein, extra-domain b, eiiib, ed-b, extracellular matrix, protein binding
Biological source	Homo sapiens (human) More
Cellular location	Secreted : P80188 Secreted, extracellular space, extracellular matrix: P02751
Total number of polymer chains	4
Total formula weight	105920.04
Authors	Schiefner, A.,Gebauer, M.,Skerra, A. (deposition date: 2012-08-07, release date: 2012-12-26, Last modification date: 2023-11-08)
Primary citation	Gebauer, M.,Schiefner, A.,Matschiner, G.,Skerra, A. Combinatorial design of an Anticalin directed against the extra-domain b for the specific targeting of oncofetal fibronectin J.Mol.Biol., 425:780-802, 2013 Cited by PubMed: 23238252 DOI: 10.1016/j.jmb.2012.12.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation