6ZZ1

Crystal structure of MLKL executioner domain in complex with a covalent inhibitor

Summary for 6ZZ1

Entry DOI	10.2210/pdb6zz1/pdb
Related	6ZVO 6zle 6zpr
Descriptor	Mixed lineage kinase domain-like protein, 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione (3 entities in total)
Functional Keywords	necroptosis, lipid binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	35821.19
Authors	Fiegen, D.,Bauer, M.,Nar, H. (deposition date: 2020-08-03, release date: 2020-12-23, Last modification date: 2024-01-31)
Primary citation	Rubbelke, M.,Fiegen, D.,Bauer, M.,Binder, F.,Hamilton, J.,King, J.,Thamm, S.,Nar, H.,Zeeb, M. Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. Proc.Natl.Acad.Sci.USA, 117:33272-33281, 2020 Cited by PubMed: 33318170 DOI: 10.1073/pnas.2017406117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.64 Å)

Structure validation