6ZZ1
Crystal structure of MLKL executioner domain in complex with a covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mixed lineage kinase domain-like protein | polymer | 153 | 17642.3 | 2 | UniProt (Q8NB16) Pfam (PF22215) | Homo sapiens (Human) | hMLKL |
| 2 | C, D (A, B) | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione | non-polymer | 268.3 | 2 | Chemie (QOK) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 150 (UniProt: Q8NB16)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35284.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 536.5 | |
| All* | Total formula weight | 35821.2 |
