6ZPR
Solution structure of MLKL executioner domain in complex with a covalent inhibitor
Summary for 6ZPR
Entry DOI | 10.2210/pdb6zpr/pdb |
Related | 6ZLE |
NMR Information | BMRB: 34528 |
Descriptor | Mixed lineage kinase domain-like protein,Mixed lineage kinase domain-like protein, 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione (2 entities in total) |
Functional Keywords | necroptosis, lipid binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 18453.23 |
Authors | Ruebbelke, M.,Bauer, M.,Hamilton, J.,Binder, F.,Nar, H.,Zeeb, M. (deposition date: 2020-07-09, release date: 2020-12-16, Last modification date: 2021-01-06) |
Primary citation | Rubbelke, M.,Fiegen, D.,Bauer, M.,Binder, F.,Hamilton, J.,King, J.,Thamm, S.,Nar, H.,Zeeb, M. Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. Proc.Natl.Acad.Sci.USA, 117:33272-33281, 2020 Cited by PubMed: 33318170DOI: 10.1073/pnas.2017406117 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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