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1A8G

HIV-1 PROTEASE IN COMPLEX WITH SDZ283-910

Summary for 1A8G
Entry DOI10.2210/pdb1a8g/pdb
Related PRD IDPRD_000417
DescriptorHIV-1 PROTEASE, benzyl [(1R)-1-({(1S,2S,3S)-1-benzyl-2-hydroxy-4-({(1S)-1-[(2-hydroxy-4-methoxybenzyl)carbamoyl]-2-methylpropyl}amino)-3-[(4-methoxybenzyl)amino]-4-oxobutyl}carbamoyl)-2,2-dimethylpropyl]carbamate (3 entities in total)
Functional Keywordsacid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22487.55
Authors
Kallen, J.,Billich, A.,Scholz, D.,Auer, M.,Kungl, A. (deposition date: 1998-03-24, release date: 1998-07-15, Last modification date: 2023-08-02)
Primary citationRinghofer, S.,Kallen, J.,Dutzler, R.,Billich, A.,Visser, A.J.,Scholz, D.,Steinhauser, O.,Schreiber, H.,Auer, M.,Kungl, A.J.
X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulations.
J.Mol.Biol., 286:1147-1159, 1999
Cited by
PubMed: 10047488
DOI: 10.1006/jmbi.1998.2533
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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