7NM5
Solution structure of MLKL executioner domain in complex with a fragment
Summary for 7NM5
| Entry DOI | 10.2210/pdb7nm5/pdb |
| NMR Information | BMRB: 34605 |
| Descriptor | Mixed lineage kinase domain-like protein, 2-[(~{S})-methoxy-(4-phenylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid (2 entities in total) |
| Functional Keywords | necroptosis, lipid binding protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 18543.35 |
| Authors | Ruebbelke, M.,Bauer, M.,Hamilton, J.,Binder, F.,Nar, H.,Zeeb, M. (deposition date: 2021-02-23, release date: 2021-09-22, Last modification date: 2023-06-14) |
| Primary citation | Rubbelke, M.,Hamilton, J.,Binder, F.,Bauer, M.,King, J.,Nar, H.,Zeeb, M. Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J.Med.Chem., 64:15629-15638, 2021 Cited by PubMed: 34672548DOI: 10.1021/acs.jmedchem.1c00686 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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