7NM4

Solution structure of MLKL executioner domain in complex with a fragment

Summary for 7NM4

Entry DOI	10.2210/pdb7nm4/pdb
NMR Information	BMRB: 34604
Descriptor	Mixed lineage kinase domain-like protein, (~{S})-1~{H}-benzimidazol-2-yl-(4-propan-2-ylphenyl)methanol (2 entities in total)
Functional Keywords	necroptosis, lipid binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18451.30
Authors	Ruebbelke, M.,Bauer, M.,Hamilton, J.,Binder, F.,Nar, H.,Zeeb, M. (deposition date: 2021-02-23, release date: 2021-09-22, Last modification date: 2024-06-19)
Primary citation	Rubbelke, M.,Hamilton, J.,Binder, F.,Bauer, M.,King, J.,Nar, H.,Zeeb, M. Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J.Med.Chem., 64:15629-15638, 2021 Cited by PubMed: 34672548 DOI: 10.1021/acs.jmedchem.1c00686 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation