2YK1
Structure of human anti-nicotine Fab fragment in complex with nicotine
Summary for 2YK1
| Entry DOI | 10.2210/pdb2yk1/pdb |
| Descriptor | FAB FRAGMENT, HEAVY CHAIN, FAB FRAGMENT, LIGHT CHAIN, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, ... (4 entities in total) |
| Functional Keywords | immune system, monoclonal antibodies, anti-smoking vaccine |
| Biological source | HOMO SAPIENS More |
| Total number of polymer chains | 2 |
| Total formula weight | 45435.49 |
| Authors | Tars, K.,Kotelovica, S.,Lipowsky, G.,Bauer, M.,Beerli, R.,Bachmann, M.,Maurer, P. (deposition date: 2011-05-25, release date: 2011-11-16, Last modification date: 2023-12-20) |
| Primary citation | Tars, K.,Kotelovica, S.,Lipowsky, G.,Bauer, M.,Beerli, R.,Bachmann, M.,Maurer, P. Different Binding Modes of Free and Carrier-Protein-Coupled Nicotine in a Human Monoclonal Antibody. J.Mol.Biol., 415:118-, 2012 Cited by PubMed: 22079050DOI: 10.1016/J.JMB.2011.10.042 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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