7CXN
 
 | | Architecture of a SARS-CoV-2 mini replication and transcription complex | | 分子名称: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | | 登録日 | 2020-09-02 | | 公開日 | 2020-11-04 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.84 Å) | | 主引用文献 | Architecture of a SARS-CoV-2 mini replication and transcription complex.
Nat Commun, 11, 2020
|
|
7CXM
 | | Architecture of a SARS-CoV-2 mini replication and transcription complex | | 分子名称: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | | 著者 | Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | | 登録日 | 2020-09-02 | | 公開日 | 2020-11-04 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Architecture of a SARS-CoV-2 mini replication and transcription complex.
Nat Commun, 11, 2020
|
|
6A73
 | | Complex structure of CSN2 with IP6 | | 分子名称: | COP9 signalosome complex subunit 2,Endolysin, INOSITOL HEXAKISPHOSPHATE, SULFATE ION | | 著者 | Liu, L, Li, D, Rao, F, Wang, T. | | 登録日 | 2018-07-02 | | 公開日 | 2019-07-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.447 Å) | | 主引用文献 | Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
8V7Z
 | |
8V81
 | | Phosphorylated, ATP-bound, inhibitor 172-bound E1371Q human cystic fibrosis transmembrane conductance regulator | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[(Z)-{(3M)-4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Gao, X, Hwang, T. | | 登録日 | 2023-12-04 | | 公開日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore
Nat Commun, 2024
|
|
2K9X
 | | Solution structure of Urm1 from Trypanosoma brucei | | 分子名称: | Uncharacterized protein | | 著者 | Zhang, W, Zhang, J, Xu, C, Wang, T, Zhang, X, Tu, X. | | 登録日 | 2008-10-27 | | 公開日 | 2009-03-10 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of Urm1 from Trypanosoma brucei
Proteins, 75, 2009
|
|
7BW7
 | | Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin. | | 分子名称: | Insulin fusion, Insulin receptor | | 著者 | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | | 登録日 | 2020-04-13 | | 公開日 | 2021-04-14 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor
To Be Published
|
|
7BW8
 | | Cryo-EM Structure for the Insulin Binding Region in the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin | | 分子名称: | Insulin fusion, Insulin receptor | | 著者 | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | | 登録日 | 2020-04-14 | | 公開日 | 2021-04-14 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor
To Be Published
|
|
7BWA
 | | Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 2 Insulin | | 分子名称: | Insulin fusion, Insulin receptor | | 著者 | Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T. | | 登録日 | 2020-04-14 | | 公開日 | 2021-04-14 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor
To Be Published
|
|
7EGQ
 | | Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading | | 分子名称: | Helicase, MAGNESIUM ION, Non-structural protein 10, ... | | 著者 | Yan, L.M, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y. | | 登録日 | 2021-03-25 | | 公開日 | 2021-07-21 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading.
Cell, 184, 2021
|
|
7EIZ
 | | Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading | | 分子名称: | Helicase, MAGNESIUM ION, Non-structural protein 10, ... | | 著者 | Yan, L, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y. | | 登録日 | 2021-04-01 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY | | 主引用文献 | Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading
Cell, 184, 2021
|
|
7ETW
 | | Cryo-EM structure of Scap/Insig complex in the present of digitonin. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Digitonin, Insulin-induced gene 2 protein, ... | | 著者 | Yan, R, Cao, P, Song, W, Li, Y, Wang, T, Qian, H, Yan, C, Yan, N. | | 登録日 | 2021-05-14 | | 公開日 | 2021-06-23 | | 最終更新日 | 2022-03-02 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural basis for sterol sensing by Scap and Insig
Cell Rep, 35, 2021
|
|
5UGK
 | | Zinc-Binding Structure of a Catalytic Amyloid from Solid-State NMR Spectroscopy | | 分子名称: | ILE-HIS-VAL-HIS-LEU-GLN-ILE, ZINC ION | | 著者 | Lee, M, Wang, T, Makhlynets, O.V, Wu, Y, Polizzi, N, Wu, H, Gosavi, P.M, Korendovych, I.V, DeGrado, W.F, Hong, M. | | 登録日 | 2017-01-09 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLID-STATE NMR | | 主引用文献 | Zinc-binding structure of a catalytic amyloid from solid-state NMR.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
7WUB
 | | Cryo-EM structure of dodecamer P97 | | 分子名称: | 3-[3-cyclopentylsulfanyl-5-[[3-methyl-4-(4-methylsulfonylphenyl)phenoxy]methyl]-1,2,4-triazol-4-yl]pyridine, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | 著者 | Liu, S, Wang, T. | | 登録日 | 2022-02-08 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cryo-EM structure of dodecamer P97 at 2.99 Angstroms resolution
To Be Published
|
|
7ZQS
 | | Cryo-EM Structure of Human Transferrin Receptor 1 bound to DNA Aptamer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (30-MER), ... | | 著者 | Bansia, H, Wang, T, Gutierrez, D, des Georges, A. | | 登録日 | 2022-05-02 | | 公開日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing.
J.Am.Chem.Soc., 144, 2022
|
|
8XEP
 | | Crystal structure of a Legionella pneumophila type IV effector in complex with ubiquitin | | 分子名称: | SULFATE ION, Type IV effector MavL, Ubiquitin | | 著者 | Tan, J.X, Wang, X.F, Zhou, Y, Zhu, Y.Q. | | 登録日 | 2023-12-12 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-07-24 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Legionella effector LnaB is a phosphoryl AMPylase that impairs phosphosignalling.
Nature, 631, 2024
|
|
3JY9
 | | Janus Kinase 2 Inhibitors | | 分子名称: | (3S)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3H)-one, SODIUM ION, Tyrosine-protein kinase JAK2 | | 著者 | Zuccola, H.J, Ledeboer, M.W, Pierce, A.C. | | 登録日 | 2009-09-21 | | 公開日 | 2009-12-01 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.
J.Med.Chem., 52, 2009
|
|
8JO4
 | | Cryo-EM structure of a Legionella effector complexed with actin and ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin, alpha skeletal muscle, ... | | 著者 | Zhou, X.T, Wang, X.F, Tan, J.X, Zhu, Y.Q. | | 登録日 | 2023-06-07 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.04 Å) | | 主引用文献 | Legionella effector LnaB is a phosphoryl AMPylase that impairs phosphosignalling.
Nature, 631, 2024
|
|
8JO3
 | | Cryo-EM structure of a Legionella effector complexed with actin and AMP | | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | 著者 | Zhou, X.T, Wang, X.F, Tan, J.X, Zhu, Y.Q. | | 登録日 | 2023-06-07 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | | 主引用文献 | Legionella effector LnaB is a phosphoryl AMPylase that impairs phosphosignalling.
Nature, 631, 2024
|
|
4ZOM
 | | RORgamma in complex with inverse agonist 4j. | | 分子名称: | N-{4-[3-(acetylamino)-1-(propan-2-yl)-1H-pyrazol-5-yl]-2-[(1R,5S)-3-azabicyclo[3.1.0]hex-3-yl]phenyl}-2-chloro-6-fluoro-N-methylbenzamide, Nuclear receptor ROR-gamma | | 著者 | Marcotte, D.J. | | 登録日 | 2015-05-06 | | 公開日 | 2015-06-17 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Discovery of novel pyrazole-containing benzamides as potent ROR gamma inverse agonists.
Bioorg.Med.Chem.Lett., 25, 2015
|
|
8JPP
 | | Cryo-EM structure of succinate receptor bound to succinate acid coupling MiniGsq | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Wang, T.X, Tang, W.Q, Li, F.H, Wang, J.Y. | | 登録日 | 2023-06-12 | | 公開日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Molecular activation and G protein coupling selectivity of human succinate receptor SUCR1.
Cell Res., 2024
|
|
8JPN
 | | Cryo-EM structure of succinate receptor bound to cis-epoxysuccinic acid coupling to Gi | | 分子名称: | (2R,3S)-oxirane-2,3-dicarboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Wang, T.X, Tang, W.Q, Li, F.H, Wang, J.Y. | | 登録日 | 2023-06-12 | | 公開日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Molecular activation and G protein coupling selectivity of human succinate receptor SUCR1.
Cell Res., 2024
|
|
8K8J
 | | Cannabinoid Receptor 1 bound to Fenofibrate coupling MiniGsq and Nb35 Complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Tang, W.Q, Wang, T.X, Li, F.H, Wang, J.Y. | | 登録日 | 2023-07-30 | | 公開日 | 2024-02-14 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Fenofibrate Recognition and G q Protein Coupling Mechanisms of the Human Cannabinoid Receptor CB1.
Adv Sci, 11, 2024
|
|
4HZU
 | | Structure of a bacterial energy-coupling factor transporter | | 分子名称: | Energy-coupling factor transporter ATP-binding protein EcfA 1, Energy-coupling factor transporter ATP-binding protein EcfA 2, Energy-coupling factor transporter transmembrane protein EcfT, ... | | 著者 | Wang, T.L, Fu, G.B, Pan, X.J, Shi, Y.G. | | 登録日 | 2012-11-15 | | 公開日 | 2013-04-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.53 Å) | | 主引用文献 | Structure of a bacterial energy-coupling factor transporter.
Nature, 497, 2013
|
|
7LXE
 | |
